DeniseCooper

Denise Cooper, Ph.D.

Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Professor, Dept. of Molecular Medicine, College of Medicine, University of South Florida

Research Career Scientist, James A. Haley Veterans Hospital

Contact Info James A. Haley Veterans' Hospital
13000 Bruce B. Downs Blvd., room 2-214
Tampa, FL 33612

Academic Email: dcooper@health.usf.edu

View My C.V.

Education

  • MS, Biochemistry and Molecular Biology, University of Oklahoma Health Sciences, 2006
  • PHD, Biochemistry and Molecular Biology, University Of Oklahoma Health Sciences Center, 1983

Interdisciplinary and Emerging Signature Programs

  • Metabolic Regulation and Disorders

Memberships

  • American Society for Cell Biology (Member, 1997 - Present)
  • American Society for Biochemistry and Molecular Biology (Member, 1987 - Present)
  • Endocrine Society (Member, 1986 - Present)
  • American Diabetes Association (Member, 1986 - Present)
  • American Heart Association (Member, 2006 - 2006)

Recent Publications

  • Sampson, SR.Cooper, DR. Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Molecular genetics and metabolism. 89(1-2) : 32-47http://www.ncbi.nlm.nih.gov/pubmed/16798038
  • Jiang, K.Apostolatos, AH.Ghansah, T.Watson, JE.Vickers, T.Cooper, DR.Epling-Burnette, PK.Patel, NA. Identification of a novel antiapoptotic human protein kinase C delta isoform, PKCdeltaVIII in NT2 cells. Biochemistry. 47(2) : 787-97, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18092819
  • Horovitz-Fried, M.Jacob, AI.Cooper, DR.Sampson, SR. Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Cellular signalling. 19(3) : 556-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17046201
  • Ghosh, N.Patel, N.Jiang, K.Watson, JE.Cheng, J.Chalfant, CE.Cooper, DR. Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells. Endocrinology. 148(3) : 1359-66, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17158207
  • Patel, NA.Song, SS.Cooper, DR. PKCdelta alternatively spliced isoforms modulate cellular apoptosis in retinoic acid-induced differentiation of human NT2 cells and mouse embryonic stem cells. Gene expression. 13(2) : 73-84, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17017122
  • Horovitz-Fried, M.Cooper, DR.Patel, NA.Cipok, M.Brand, C.Bak, A.Inbar, A.Jacob, AI.Sampson, SR. Insulin rapidly upregulates protein kinase Cdelta gene expression in skeletal muscle. Cellular signalling. 18(2) : 183-93, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16095881
  • Patel, NA.Kaneko, S.Apostolatos, HS.Bae, SS.Watson, JE.Davidowitz, K.Chappell, DS.Birnbaum, MJ.Cheng, JQ.Cooper, DR. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. The Journal of biological chemistry. 280(14) : 14302-9, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15684423
  • Patel, NA.Apostolatos, HS.Mebert, K.Chalfant, CE.Watson, JE.Pillay, TS.Sparks, J.Cooper, DR. Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene. Molecular endocrinology (Baltimore, Md.). 18(4) : 899-911, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14752056
  • Patel, NA.Eichler, DC.Chappell, DS.Illingworth, PA.Chalfant, CE.Yamamoto, M.Dean, NM.Wyatt, JR.Mebert, K.Watson, JE.Cooper, DR. The protein kinase C beta II exon confers mRNA instability in the presence of high glucose concentrations. The Journal of biological chemistry. 278(2) : 1149-57, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12407109
  • Okumura, M.Yamamoto, M.Sakuma, H.Kojima, T.Maruyama, T.Jamali, M.Cooper, DR.Yasuda, K. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochimica et biophysica acta. 1592(2) : 107-16, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12379472
  • Patel, NA.Yamamoto, M.Illingworth, P.Mancu, D.Mebert, K.Chappell, DS.Watson, JE.Cooper, DR. Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose. Archives of biochemistry and biophysics. 403(1) : 111-20, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12061808
  • Jenq, W.Ramirez, G.Peguero, A.Cooper, DR.Vesely, DL. D-glucose and NaCl enhance the expression of aquaporin-1: inhibition of both by cholera toxin. Nephron. 92(2) : 279-86, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12218304
  • Patel, NA.Chalfant, CE.Watson, JE.Wyatt, JR.Dean, NM.Eichler, DC.Cooper, DR. Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells. The Journal of biological chemistry. 276(25) : 22648-54, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11283022
  • Yamamoto, M.Acevedo-Duncan, M.Chalfant, CE.Patel, NA.Watson, JE.Cooper, DR. Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation. American journal of physiology. Cell physiology. 279(3) : C587-95, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10942708
  • Sanchez-Ramos, J.Song, S.Cardozo-Pelaez, F.Hazzi, C.Stedeford, T.Willing, A.Freeman, TB.Saporta, S.Janssen, W.Patel, N.Cooper, DR.Sanberg, PR. Adult bone marrow stromal cells differentiate into neural cells in vitro. Experimental neurology. 164(2) : 247-56, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10915564
  • Chalfant, CE.Ciaraldi, TP.Watson, JE.Nikoulina, S.Henry, RR.Cooper, DR. Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity. Endocrinology. 141(8) : 2773-8, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10919262
  • Yan, SF.Lu, J.Zou, YS.Soh-Won, J.Cohen, DM.Buttrick, PM.Cooper, DR.Steinberg, SF.Mackman, N.Pinsky, DJ.Stern, DM. Hypoxia-associated induction of early growth response-1 gene expression. The Journal of biological chemistry. 274(21) : 15030-40, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10329706
  • Patel, NA.Chalfant, CE.Yamamoto, M.Watson, JE.Eichler, DC.Cooper, DR. Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 13(1) : 103-13, 1999. http://www.ncbi.nlm.nih.gov/pubmed/9872935
  • Jenq, W.Cooper, DR.Bittle, P.Ramirez, G. Aquaporin-1 expression in proximal tubule epithelial cells of human kidney is regulated by hyperosmolarity and contrast agents. Biochemical and biophysical research communications. 256(1) : 240-8, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10066454
  • Yamamoto, M.Patel, NA.Taggart, J.Sridhar, R.Cooper, DR. A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-betaII. International journal of cancer. Journal international du cancer. 83(1) : 98-106, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10449615
  • Cooper, DR.Watson, JE.Patel, N.Illingworth, P.Acevedo-Duncan, M.Goodnight, J.Chalfant, CE.Mischak, H. Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells. Archives of biochemistry and biophysics. 372(1) : 69-79, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10562418
  • Yamamoto, M.Acevedo-Duncan, M.Chalfant, CE.Patel, NA.Watson, JE.Cooper, DR. The roles of protein kinase C beta I and beta II in vascular smooth muscle cell proliferation. Experimental cell research. 240(2) : 349-58, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9597008
  • Chalfant, CE.Watson, JE.Bisnauth, LD.Kang, JB.Patel, N.Obeid, LM.Eichler, DC.Cooper, DR. Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection. The Journal of biological chemistry. 273(2) : 910-6, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9422749
  • Perrotti, D.Bonatti, S.Trotta, R.Martinez, R.Skorski, T.Salomoni, P.Grassilli, E.Lozzo, RV.Cooper, DR.Calabretta, B. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. The EMBO journal. 17(15) : 4442-55, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9687511
  • Acevedo-Duncan, M.Zhang, R.Cooper, DR.Greenberg, HM. Effects of interferon and PKC modulators on human glioma protein kinase C, cell proliferation, and cell cycle. Neurochemical research. 22(7) : 775-84, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9232628
  • Chalfant, CE.Ohno, S.Konno, Y.Fisher, AA.Bisnauth, LD.Watson, JE.Cooper, DR. A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. Molecular endocrinology (Baltimore, Md.). 10(10) : 1273-81, 1996. http://www.ncbi.nlm.nih.gov/pubmed/9121494
  • Coulson, R.Proch, PS.Olsson, RA.Chalfant, CE.Cooper, DR. Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation. The American journal of physiology. 270(2 Pt 2) : F263-74, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8779886
  • Jenq, W.Cooper, DR.Ramirez, G. Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. Connective tissue research. 34(3) : 161-74, 1996. http://www.ncbi.nlm.nih.gov/pubmed/9023046
  • Yamada, K.Avignon, A.Standaert, ML.Cooper, DR.Spencer, B.Farese, RV. Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. The Biochemical journal. 308 ( Pt 1): 177-80, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7755563
  • Chalfant, CE.Mischak, H.Watson, JE.Winkler, BC.Goodnight, J.Farese, RV.Cooper, DR. Regulation of alternative splicing of protein kinase C beta by insulin. The Journal of biological chemistry. 270(22) : 13326-32, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7768933
  • Acevedo-Duncan, M.Collins, J.Zhang, R.Haller, E.Chalfant, CE.Cooper, DR. In situ effects of interferon on human glioma protein kinase C-alpha and -beta ultrastructural localization. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 6(11) : 1353-65, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8562473
  • Zhao, L.Standaert, ML.Cooper, DR.Avignon, A.Farese, RV. Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation. Endocrinology. 135(6) : 2504-10, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7988438
  • Farese, RV.Standaert, ML.Yamada, K.Huang, LC.Zhang, C.Cooper, DR.Wang, Z.Yang, Y.Suzuki, S.Toyota, T. Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proceedings of the National Academy of Sciences of the United States of America. 91(23) : 11040-4, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7972005
  • Standaert, ML.Musunuru, K.Yamada, K.Cooper, DR.Farese, RV. Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. Cellular signalling. 6(6) : 707-16, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7857772
  • Gower, WR.Dietz, JR.Vesely, DL.Finley, CL.Skolnick, KA.Fabri, PJ.Cooper, DR.Chalfant, CE. Atrial natriuretic peptide gene expression in the rat gastrointestinal tract. Biochemical and biophysical research communications. 202(1) : 562-70, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8037763
  • Yamada, K.Standaert, ML.Yu, B.Mischak, H.Cooper, DR.Farese, RV. Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes. Archives of biochemistry and biophysics. 312(1) : 167-72, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8031124
  • Farese, RV.Standaert, ML.Arnold, TP.Yamada, K.Musunuru, K.Hernandez, H.Mischak, H.Cooper, DR. Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. The Journal of clinical investigation. 93(5) : 1894-9, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8182122
  • Farese, RV.Standaert, M.Yu, B.Hernandez, H.Cooper, DR. 2-Hydroxypropyl-beta-cyclodextrin enhances phorbol ester effects on glucose transport and/or protein kinase C-beta translocation to the plasma membrane in rat adipocytes and soleus muscles. The Journal of biological chemistry. 268(27) : 19949-55, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8376357
  • Arnold, TP.Standaert, ML.Hernandez, H.Watson, J.Mischak, H.Kazanietz, MG.Zhao, L.Cooper, DR.Farese, RV. Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes. The Biochemical journal. 295 ( Pt 1): 155-64, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8216211
  • Cooper, DR.Watson, JE.Dao, ML. Decreased expression of protein kinase-C alpha, beta, and epsilon in soleus muscle of Zucker obese (fa/fa) rats. Endocrinology. 133(5) : 2241-7, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8404676
  • Standaert, ML.Cooper, DR.Hernandez, H.Arnold, TP.Farese, RV. Differential down-regulation of insulin-sensitive protein kinase-C isoforms by 12-O-tetradecanoylphorbol-13-acetate in rat adipocytes and BC3H-1 myocytes. Endocrinology. 132(2) : 689-92, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8425487
  • Cooper, DR.Khalakdina, A.Watson, JE. Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells. Archives of biochemistry and biophysics. 302(2) : 490-8, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8489251
  • Cooper, DR.Watson, JE.Hernandez, H.Yu, B.Standaert, ML.Ways, DK.Arnold, TT.Ishizuka, T.Farese, RV. Direct evidence for protein kinase C involvement in insulin-stimulated hexose uptake. Biochemical and biophysical research communications. 188(1) : 142-8, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1417838
  • Farese, RV.Standaert, ML.Arnold, T.Yu, B.Ishizuka, T.Hoffman, J.Vila, M.Cooper, DR. The role of protein kinase C in insulin action. Cellular signalling. 4(2) : 133-43, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1616820
  • Yu, B.Standaert, M.Arnold, T.Hernandez, H.Watson, J.Ways, K.Cooper, DR.Farese, RV. Effects of insulin on diacylglycerol/protein kinase-C signalling and glucose transport in rat skeletal muscles in vivo and in vitro. Endocrinology. 130(6) : 3345-55, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1597146
  • Farese, RV.Standaert, ML.Francois, AJ.Ways, K.Arnold, TP.Hernandez, H.Cooper, DR. Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes. The Biochemical journal. 288 ( Pt 1): 319-23, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1445277
  • Farese, RV.Standaert, ML.Cooper, DR. Protein kinase C downregulation? Nature. 360(6402) : 305, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1448147
  • Standaert, ML.Sasse, J.Cooper, DR.Farese, RV. Protein kinase C(19-31) pseudosubstrate inhibition of insulin action in rat adipocytes. FEBS letters. 282(1) : 139-42, 1991. http://www.ncbi.nlm.nih.gov/pubmed/2026249
  • Farese, RV.Standaert, ML.Ishizuka, T.Yu, B.Arnold, TP.Cooper, DR. The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport. Transactions of the Association of American Physicians. 104: 187-93, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1845144
  • Farese, RV.Standaert, ML.Ishizuka, T.Yu, B.Hernandez, H.Waldron, C.Watson, J.Farese, JP.Cooper, DR.Wickstrom, E. Antisense DNA downregulates protein kinase C isozymes (beta and alpha) and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes. Antisense research and development. 1(1) : 35-42, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1822247
  • Farese, RV.Ishizuka, T.Standaert, ML.Cooper, DR. Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes. Metabolism: clinical and experimental. 40(2) : 196-200, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1899124
  • Coulson, R.Johnson, RA.Olsson, RA.Cooper, DR.Scheinman, SJ. Adenosine stimulates phosphate and glucose transport in opossum kidney epithelial cells. The American journal of physiology. 260(6 Pt 2) : F921-8, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1647692
  • Ishizuka, T.Cooper, DR.Arnold, T.Hernandez, H.Farese, RV. Downregulation of protein kinase C and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes by phorbol esters, glucose, and insulin. Diabetes. 40(10) : 1274-81, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1936590
  • Ishizuka, T.Cooper, DR.Hernandez, H.Buckley, D.Standaert, M.Farese, RV. Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport. Diabetes. 39(2) : 181-90, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2227125
  • Cooper, DR.Ishizuka, T.Watson, JE.Standaert, ML.Nair, G.Farese, RV. Protein kinase C activation patterns are determined by methodological variations. Studies of insulin action in BC3H-1 myocytes and rat adipose tissue. Biochimica et biophysica acta. 1054(1) : 95-102, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2200530
  • Cooper, DR.Hernandez, H.Kuo, JY.Farese, RV. Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes. Archives of biochemistry and biophysics. 276(2) : 486-94, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2106290
  • Cooper, DR.Vila, MC.Watson, JE.Nair, G.Pollet, RJ.Standaert, M.Farese, RV. Sulfonylurea-stimulated glucose transport association with diacylglycerollike activation of protein kinase C in BC3H1 myocytes. Diabetes. 39(11) : 1399-407, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2121569
  • Standaert, ML.Buckley, DJ.Ishizuka, T.Hoffman, JM.Cooper, DR.Pollet, RJ.Farese, RV. Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes. Metabolism: clinical and experimental. 39(11) : 1170-9, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2233279
  • Ishizuka, T.Cooper, DR.Farese, RV. Insulin provokes apparent increases in rat adipocyte M-kinase. Biochemical and biophysical research communications. 169(3) : 966-72, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2194457
  • Cooper, DR.Watson, JE.Acevedo-Duncan, M.Pollet, RJ.Standaert, ML.Farese, RV. Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. Biochemical and biophysical research communications. 161(1) : 327-34, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2730662
  • Ishizuka, T.Hoffman, J.Cooper, DR.Watson, JE.Pushkin, DB.Farese, RV. Glucose-induced synthesis of diacylglycerol de novo is associated with translocation (activation) of protein kinase C in rat adipocytes. FEBS letters. 249(2) : 234-8, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2737282
  • Farese, RV.Nair, GP.Sierra, CG.Standaert, ML.Pollet, RJ.Cooper, DR. Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes. The Biochemical journal. 261(3) : 927-34, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2803252
  • Ishizuka, T.Cooper, DR.Farese, RV. Insulin stimulates the translocation of protein kinase C in rat adipocytes. FEBS letters. 257(2) : 337-40, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2684690
  • Farese, RV.Cooper, DR. Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance. Diabetes/metabolism reviews. 5(5) : 455-74, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2667929
  • Vila, MC.Cooper, DR.Davis, JS.Standaert, ML.Farese, RV. Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action. FEBS letters. 244(1) : 177-80, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2647517
  • Acevedo-Duncan, M.Cooper, DR.Standaert, ML.Farese, RV. Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes. FEBS letters. 244(1) : 174-6, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2647516
  • Wallin, BA.McCafferty, JP.Fox, MJ.Cooper, DR.Goldschmidt, MS. Incidence and management of diarrhea during longterm auranofin therapy. The Journal of rheumatology. 15(12) : 1755-8, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3265956
  • Farese, RV.Cooper, DR.Konda, TS.Nair, G.Standaert, ML.Davis, JS.Pollet, RJ. Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes. The Biochemical journal. 256(1) : 175-84, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3146971
  • Farese, RV.Nair, GP.Standaert, ML.Cooper, DR. Epidermal growth factor and insulin-like growth factor I stimulate the hydrolysis of the insulin-sensitive phosphatidylinositol-glycan in BC3H-1 myocytes. Biochemical and biophysical research communications. 156(3) : 1346-52, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3056411
  • Farese, RV.Cooper, DR.Konda, TS.Nair, G.Standaert, ML.Pollet, RJ. Insulin provokes co-ordinated increases in the synthesis of phosphatidylinositol, phosphatidylinositol phosphates and the phosphatidylinositol-glycan in BC3H-1 myocytes. The Biochemical journal. 256(1) : 185-8, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2851976
  • Nair, GP.Standaert, ML.Pollet, RJ.Cooper, DR.Farese, RV. Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes. Biochemical and biophysical research communications. 154(3) : 1345-9, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3044366
  • Standaert, ML.Farese, RV.Cooper, DR.Pollet, RJ. Insulin-induced glycerolipid mediators and the stimulation of glucose transport in BC3H-1 myocytes. The Journal of biological chemistry. 263(18) : 8696-705, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3288620
  • Farese, RV.Fanjul, LF.de Ruiz Galarreta, CM.Davis, JS.Cooper, DR. ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo. Life sciences. 41(24) : 2631-7, 1987. http://www.ncbi.nlm.nih.gov/pubmed/2826946

Positions Held

  • Research Scientist/Investigator James A. Haley Veterans Hospital 1986 - 2002)
  • Associate Professor (Dept. of Internal Medicine, College of Medicine, University of South Florida 1997 - 2000)
  • Associate Professor (Dept. of Biochemistry and Molecular Biology, College of Medicine, University of South Florida 1995 - 2000)
  • Assistant Professor (Dept. of Medicine, Division of Endocrinology and Medicine, College of Medicine, University of South Florida 1987 - 1997)
  • Assistant Professor (Dept. of Biochemistry and Molecular Biology, College of Medicine, University of South Florida 1992 - 1995)
  • Postdoctoral Fellow (Dept. of Medicine, James A. Haley Veterans Hospital, University of South Florida 1985 - 1986)
  • Associate Research Scientist (Biomembrane Research Program, Oklahoma Medical Research Foundation 1983 - 1985)