KennethUgen

Kenneth Ugen, Ph.D.

Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Professor, Molecular Medicine, UNIVERSITY of SOUTH FLORIDA

Contact Info Molecular Medicine
COM MDC 7
Tampa, FL 33612

Academic Email: kugen@health.usf.edu

Academic Phone: (813) 974-1917

View My C.V.

Education

  • PHD, Developmental Biology, University Of Cincinnati, 1986
  • B.S., Biological Sciences, UNIVERSITY OF PITTSBURGH, 1980

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Cancer Biology

Research Interests

  • My research focuses on applied and translational immunology
  • with the goal of developing and characterizing novel gene based
  • vaccines and therapies against infectious agents and cancer.
  • Previous funded work has centered on vaccine development
  • against neurodegenerative diseases such as Alzheimers Disease
  • as well as the development of vaccines and immunotherapeutics
  • against HIV. Current research emphasis is centering on methods
  • for delivering novel gene and peptide based therapies against cancer
  • Basic molecular and immunological methods are being used in the
  • lab to pursue these goals

Memberships

  • American Association for Cancer Research (Member, 2007 - Present)
  • American Society for Gene Therapy (Member, 2007 - Present)

Recent Publications

  • Connolly, RJ.Chapman, T.Hoff, AM.Kutzler, MA.Jaroszeski, MJ.Ugen, KE. Non-contact helium-based plasma for delivery of DNA vaccines: Enhancement of humoral and cellular immune responses. Human vaccines & immunotherapeutics. 8(11) , 2012. http://www.ncbi.nlm.nih.gov/pubmed/22894954
  • Ugen, KE.Weiner, DB. Highlights of the DNA Vaccines 2011 Meeting. Human vaccines & immunotherapeutics. 8(11) , 2012. http://www.ncbi.nlm.nih.gov/pubmed/23151444
  • Connolly, RJ.Rey, JI.Lambert, VM.Wegerif, G.Jaroszeski, MJ.Ugen, KE. Enhancement of antigen specific humoral immune responses after delivery of a DNA plasmid based vaccine through a contact-independent helium plasma. Vaccine. 29(39) : 6781-4, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21195804
  • Marshall, WG.Boone, BA.Burgos, JD.Gografe, SI.Baldwin, MK.Danielson, ML.Larson, MJ.Caretto, DR.Cruz, Y.Ferraro, B.Heller, LC.Ugen, KE.Jaroszeski, MJ.Heller, R. Electroporation-mediated delivery of a naked DNA plasmid expressing VEGF to the porcine heart enhances protein expression. Gene therapy. 17(3) : 419-23, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19956270
  • Kutzler, MA.Kraynyak, KA.Nagle, SJ.Parkinson, RM.Zharikova, D.Chattergoon, M.Maguire, H.Muthumani, K.Ugen, K.Weiner, DB. Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. Gene therapy. 17(1) : 72-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19847203
  • Muthumani, K.Lambert, VM.Sardesai, NY.Kim, JJ.Heller, R.Weiner, DB.Ugen, KE. Analysis of the potential for HIV-1 Vpr as an anti-cancer agent. Current HIV research. 7(2) : 144-52, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19275583
  • Muthumani, K.Lambert, VM.Shanmugam, M.Thieu, KP.Choo, AY.Chung, JC.Satishchandran, A.Kim, JJ.Weiner, DB.Ugen, KE. Anti-tumor activity mediated by protein and peptide transduction of HIV viral protein R (Vpr). Cancer biology & therapy. 8(2) : 180-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19029839
  • Fiala,M., Singer,E.J., Comminism,D., Mirzapoiazova,T., Verin,A., Espinoza,A.,Ugen,K., Bernas,M., Witte,M., Weinard,M. and Lossinsky,A.S. HIV-1 antigens in neurons of cocaine-abusing patients The Open Virology Journal. 2: 24-31, 2008.
  • Solórzano-Vargas, RS.Vasilevko, V.Acero, G.Ugen, KE.Martinez, R.Govezensky, T.Vazquez-Ramirez, R.Kubli-Garfias, C.Cribbs, DH.Manoutcharian, K.Gevorkian, G. Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Molecular immunology. 45(4) : 881-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/17889938
  • Daud, AI.DeConti, RC.Andrews, S.Urbas, P.Riker, AI.Sondak, VK.Munster, PN.Sullivan, DM.Ugen, KE.Messina, JL.Heller, R. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(36) : 5896-903, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19029422
  • McCray, AN.Ugen, KE.Heller, R. Enhancement of anti-melanoma activity of a plasmid expressing HIV-1 Vpr delivered through in vivo electroporation. Cancer biology & therapy. 6(8) : 1269-75, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17700061
  • Li, Q.Gordon, M.Cao, C.Ugen, KE.Morgan, D. Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies. BMC neuroscience. 8: 22, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17374155
  • Ugen, KE.Nyland, SB. Injecting drugs of abuse and immunity: implications for HIV vaccine testing and efficacy. Springer seminars in immunopathology. 28(3) : 281-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17109182
  • Kutzler, MA.Cao, C.Bai, Y.Dong, H.Choe, PY.Saulino, V.McLaughlin, L.Whelan, A.Choo, AY.Weiner, DB.Ugen, KE. Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice. Vaccine. 24(21) : 4630-9, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16157426
  • Ugen, KE.Kutzler, MA.Marrero, B.Westover, J.Coppola, D.Weiner, DB.Heller, R. Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation. Cancer gene therapy. 13(10) : 969-74, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16763607
  • McCray, AN.Ugen, KE.Muthumani, K.Kim, JJ.Weiner, DB.Heller, R. Complete regression of established subcutaneous B16 murine melanoma tumors after delivery of an HIV-1 Vpr-expressing plasmid by in vivo electroporation. Molecular therapy : the journal of the American Society of Gene Therapy. 14(5) : 647-55, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16950655
  • Nyland,S., Loughran,T.P. and Ugen,K.E. Human T Cell Lymphotropic Virus Types I and II Manual of Molecular and Clinical Laboratory Immunology. 1: 798-802, 2006.
  • MacGregor, RR.Boyer, JD.Ugen, KE.Tebas, P.Higgins, TJ.Baine, Y.Ciccarelli, RB.Ginsberg, RS.Weiner, DB. Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral "blips". Vaccine. 23(17-18) : 2066-73, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15755572
  • Ugen,K.E. and Wang,B. Severe acute respiratory syndrome: pathology, animal models and vaccine development DNA and Cell Biology. 24: 477-478, 2005.
  • Kutzler, M., Ugen,K.E., and Weiner,D.B. Smallpox: Pathogenesis and Host Immune Response Relevant to Vaccine and Therapeutic Strategies for This Potential Bioterror Agent Microorganisms and Bioterrorism. (1) : 63-81, 2005.
  • Heller, LC.Ugen, K.Heller, R. Electroporation for targeted gene transfer. Expert opinion on drug delivery. 2(2) : 255-68, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16296752
  • Ferrantelli, F.Kitabwalla, M.Rasmussen, RA.Cao, C.Chou, TC.Katinger, H.Stiegler, G.Cavacini, LA.Bai, Y.Cotropia, J.Ugen, KE.Ruprecht, RM. Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine. The Journal of infectious diseases. 189(1) : 71-4, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14702155
  • Manoutcharian, K.Acero, G.Munguia, ME.Becerril, B.Massieu, L.Govezensky, T.Ortiz, E.Marks, JD.Cao, C.Ugen, K.Gevorkian, G. Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42. Neurobiology of disease. 17(1) : 114-21, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15350972
  • Muthumani, K.Choo, AY.Hwang, DS.Ugen, KE.Weiner, DB. HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis. Current drug delivery. 1(4) : 335-44, 2004. http://www.ncbi.nlm.nih.gov/pubmed/16305395
  • Wilcock, DM.Munireddy, SK.Rosenthal, A.Ugen, KE.Gordon, MN.Morgan, D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiology of disease. 15(1) : 11-20, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14751766
  • Giri, M.Ugen, KE.Weiner, DB. DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clinical microbiology reviews. 17(2) : 370-89, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15084506
  • Cao, C.Bai, Y.Holloway, MJ.Edgeworth, RL.Jackson, EA.Cotropia, J.Ugen, KE. Characterization of a novel human anti-HIV-1 gp41 IgM monoclonal antibody designated clone 37. DNA and cell biology. 23(12) : 836-41, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15684710
  • Li, Q.Cao, C.Chackerian, B.Schiller, J.Gordon, M.Ugen, KE.Morgan, D. Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. BMC neuroscience. 5: 21, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15186505
  • Manoutcharian, K.Acero, G.Munguia, ME.Montero, JA.Govezensky, T.Cao, C.Ugen, K.Gevorkian, G. Amyloid-beta peptide-specific single chain Fv antibodies isolated from an immune phage display library. Journal of neuroimmunology. 145(1-2) : 12-7, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14644026
  • Ugen, KE.Heller, R. Electroporation as a method for the efficient in vivo delivery of therapeutic genes. DNA and cell biology. 22(12) : 753, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14683585
  • CAo,C., Ugen,K.E., Dickey,C., Wilcock,D, Bai,Y., Gordon,M.N. and Morgan,D. Characterization of amyloid beta vaccination strategies in mice Fondation IPSEN Pour La Recherche Therapeutique. 1: 21-31, 2003.
  • Morgan,D., Jantzen,P., Wilcock,D., DiCarlo,G., Ugen,K. and Gordon,M. The association of microglial activation and amyloid resuction in APP+PS1 transgenic mice Current Medicinal Chemistry, Immunology, Endocrine and Metabolic Agents. 3: 233-243, 2003.
  • Wilcock, DM.DiCarlo, G.Henderson, D.Jackson, J.Clarke, K.Ugen, KE.Gordon, MN.Morgan, D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(9) : 3745-51, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12736345
  • Austin, L.Arendash, GW.Gordon, MN.Diamond, DM.DiCarlo, G.Dickey, C.Ugen, K.Morgan, D. Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. Behavioral neuroscience. 117(3) : 478-84, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12802876
  • Muthumani, K.Bagarazzi, M.Conway, D.Hwang, DS.Manson, K.Ciccarelli, R.Israel, Z.Montefiori, DC.Ugen, K.Miller, N.Kim, J.Boyer, J.Weiner, DB. A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques. Vaccine. 21(7-8) : 629-37, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12531331
  • Nyland, SB.Cao, C.Bai, Y.Loughran, TP.Ugen, KE. Modulation of infection and type 1 cytokine expression parameters by morphine during in vitro coinfection with human T-cell leukemia virus type I and HIV-1. Journal of acquired immune deficiency syndromes (1999). 32(4) : 406-16, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12640199
  • Nyland,S.B., Cao,C. and Ugen,K.E. Human T Cell Lymphotropic Virus Type I and II Manual of Clinical Laboratory Immunology. 1: 749-753, 2002.
  • Edgeworth, RL.San, JH.Rosenzweig, JA.Nguyen, NL.Boyer, JD.Ugen, KE. Vaccine development against HIV-1: current perspectives and future directions. Immunologic research. 25(1) : 53-74, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11868934
  • Gómez-Román, VR.Cao, C.Bai, Y.Santamaría, H.Acero, G.Manoutcharian, K.Weiner, DB.Ugen, KE.Gevorkian, G. Phage-displayed mimotopes recognizing a biologically active anti-HIV-1 gp120 murine monoclonal antibody. Journal of acquired immune deficiency syndromes (1999). 31(2) : 147-53, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12394792
  • MacGregor, RR.Ginsberg, R.Ugen, KE.Baine, Y.Kang, CU.Tu, XM.Higgins, T.Weiner, DB.Boyer, JD. T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev. AIDS (London, England). 16(16) : 2137-43, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12409734
  • Wilcock, DM.Gordon, MN.Ugen, KE.Gottschall, PE.DiCarlo, G.Dickey, C.Boyett, KW.Jantzen, PT.Connor, KE.Melachrino, J.Hardy, J.Morgan, D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA and cell biology. 20(11) : 731-6, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11788051
  • Dickey, CA.Morgan, DG.Kudchodkar, S.Weiner, DB.Bai, Y.Cao, C.Gordon, MN.Ugen, KE. Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA and cell biology. 20(11) : 723-9, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11788050
  • Kim, JJ.Yang, JS.Nottingham, LK.Lee, DJ.Lee, M.Manson, KH.Wyand, MS.Boyer, JD.Ugen, KE.Weiner, DB. Protection from immunodeficiency virus challenges in rhesus macaques by multicomponent DNA immunization. Virology. 285(2) : 204-17, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11437655
  • Ugen, KE.Morgan, D. Alzheimer's disease: molecularly based immunotherapeutics. DNA and cell biology. 20(11) : 677-8, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11788044
  • Han, TK.Yoder, S.Cao, C.Ugen, KE.Dao, ML. Expression of Streptococcus mutans wall-associated protein A gene in Chinese hamster ovary cells: prospect for a dental caries DNA vaccine. DNA and cell biology. 20(9) : 595-601, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11747611
  • Nyland, SB.Specter, S.Ugen, KE. Direct vs. indirect modulation of complex in vitro human retroviral infections by morphine. Advances in experimental medicine and biology. 493: 49-58, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11727780
  • Sin, JI.Kim, J.Chattergoon, M.Ayyavoo, V.McCallus, D.Ugen, KE.Boyer, JD.Weiner, DB. Engineering of DNA vaccines using molecular adjuvant plasmids. Developments in biologicals. 104: 187-98, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11713819
  • Dickey, C.Ziegner, U.Agadjanyan, MG.Srikantan, V.Refaeli, Y.Prabhu, A.Sato, A.Williams, WV.Weiner, DB.Ugen, KE. Murine monoclonal antibodies biologically active against the amino region of HIV-1 gp120: isolation and characterization. DNA and cell biology. 19(4) : 243-52, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10798448
  • Morgan, D.Diamond, DM.Gottschall, PE.Ugen, KE.Dickey, C.Hardy, J.Duff, K.Jantzen, P.DiCarlo, G.Wilcock, D.Connor, K.Hatcher, J.Hope, C.Gordon, M.Arendash, GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408(6815) : 982-5, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11140686
  • Kim, JJ.Nottingham, LK.Tsai, A.Lee, DJ.Maguire, HC.Oh, J.Dentchev, T.Manson, KH.Wyand, MS.Agadjanyan, MG.Ugen, KE.Weiner, DB. Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvants. Journal of medical primatology. 28(4-5) : 214-23, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10593488
  • Edgeworth, RL.Ugen, KE. Immunopathological factors for vertical transmission of HIV-1. Pathobiology : journal of immunopathology, molecular and cellular biology. 68(2) : 53-67, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10878502
  • Cotropia,J.P. and Ugen,K.E. Passive Immunotherapy Against HIV-1: Current Status and Potential Human Retroviral Infections: Immunotherpeutic and Therapeutic Control. 1: 217-238, 2000.
  • Kim, JJ.Yang, JS.VanCott, TC.Lee, DJ.Manson, KH.Wyand, MS.Boyer, JD.Ugen, KE.Weiner, DB. Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants. Journal of virology. 74(7) : 3427-9, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10708463
  • Boyer, JD.Cohen, AD.Ugen, KE.Edgeworth, RL.Bennett, M.Shah, A.Schumann, K.Nath, B.Javadian, A.Bagarazzi, ML.Kim, J.Weiner, DB. Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids. AIDS (London, England). 14(11) : 1515-22, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10983638
  • Yoder, S.Cao, C.Ugen, KE.Dao, ML. High-level expression of a truncated wall-associated protein A from the dental cariogenic Streptococcus mutans. DNA and cell biology. 19(7) : 401-8, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10945230
  • Viveros, M.Dickey, C.Cotropia, JP.Gevorkian, G.Larralde, C.Broliden, K.Levi, M.Burgess, A.Cao, C.Weiner, DB.Agadjanyan, MG.Ugen, KE. Characterization of a novel human immunodeficiency virus type 1 neutralizable epitope within the immunodominant region of gp41. Virology. 270(1) : 135-45, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10772986
  • Boyer, JD.Chattergoon, MA.Ugen, KE.Shah, A.Bennett, M.Cohen, A.Nyland, S.Lacy, KE.Bagarazzi, ML.Higgins, TJ.Baine, Y.Ciccarelli, RB.Ginsberg, RS.MacGregor, RR.Weiner, DB. Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial. Clinical immunology (Orlando, Fla.). 90(1) : 100-7, 1999. http://www.ncbi.nlm.nih.gov/pubmed/9884357
  • Nyland, SB.Specter, S.Ugen, KE. Morphine effects on HTLV-I infection in the presence or absence of concurrent HIV-1 infection. DNA and cell biology. 18(4) : 285-91, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10235111
  • Kang, LC.Kerben, MJ.Ugen, KE.Specter, SC. Modulation of ex vivo cytokine production by splenocytes using in vitro combined therapeutics in murine retroviral model. DNA and cell biology. 18(7) : 585-92, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10433557
  • Bagarazzi, ML.Boyer, JD.Javadian, MA.Chattergoon, MA.Shah, AR.Cohen, AD.Bennett, MK.Ciccarelli, RB.Ugen, KE.Weiner, DB. Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees. The Journal of infectious diseases. 180(4) : 1351-5, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10479171
  • Boyer, JD.Kim, J.Ugen, K.Cohen, AD.Ahn, L.Schumann, K.Lacy, K.Bagarazzi, ML.Javadian, A.Ciccarelli, RB.Ginsberg, RS.MacGregor, RR.Weiner, DB. HIV-1 DNA vaccines and chemokines. Vaccine. 17 Suppl 2: S53-64, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10506409
  • Ugen, KE.Nyland, SB.Boyer, JD.Vidal, C.Lera, L.Rasheid, S.Chattergoon, M.Bagarazzi, ML.Ciccarelli, R.Higgins, T.Baine, Y.Ginsberg, R.Macgregor, RR.Weiner, DB. DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans. Vaccine. 16(19) : 1818-21, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9795386
  • Noe, SN.Nyland, SB.Ugen, K.Friedman, H.Klein, TW. Cannabinoid receptor agonists enhance syncytia formation in MT-2 cells infected with cell free HIV-1MN. Advances in experimental medicine and biology. 437: 223-9, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9666275
  • MacGregor, RR.Boyer, JD.Ugen, KE.Lacy, KE.Gluckman, SJ.Bagarazzi, ML.Chattergoon, MA.Baine, Y.Higgins, TJ.Ciccarelli, RB.Coney, LR.Ginsberg, RS.Weiner, DB. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. The Journal of infectious diseases. 178(1) : 92-100, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9652427
  • Bagarazzi, ML.Boyer, JD.Ugen, KE.Javadian, MA.Chattergoon, M.Shah, A.Bennett, M.Ciccarelli, R.Carrano, R.Coney, L.Weiner, DB. Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees. Vaccine. 16(19) : 1836-41, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9795389
  • Boyer, J.Ugen, K.Wang, B.Chattergoon, M.Tsai, A.Merva, M.Weiner, DB. Induction of a TH1 type cellular immune response to the human immunodeficiency type 1 virus by in vivo DNA inoculation. Developments in biological standardization. 92: 169-74, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9554272
  • Nyland, SB.Specter, S.Im-Sin, J.Ugen, KE. Opiate effects on in vitro human retroviral infection. Advances in experimental medicine and biology. 437: 91-100, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9666261
  • Sin, JI.Kim, JJ.Ugen, KE.Ciccarelli, RB.Higgins, TJ.Weiner, DB. Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes. European journal of immunology. 28(11) : 3530-40, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9842896
  • Ugen, K.E., Rushing,G., Vidal, C., Kim,J.,, Javadian,A., Boyer,J. and Weiner, D.B. Beta chemokine levels in non-human primates modulated in vivo by HIv-1 DNA vaccines World AIDS Conference Proceedings. 5: 55-59, 1998.
  • Kim,J.J., Nottingham,L.K., Tsai,A., Morrison,L.D., Oh,J., Dentchev,T., VanCott,T.C., Manson, K.H., Ugen,K.E. and Weiner,D.B. Modulation of protective immunity in macaques using molecular adjuvants World AIDS Conference Proceedings. 5: 35-39, 1998.
  • Boyer,J.D., Bennett,M., Chattergoon,M.A., Ugen,K.E., Shah,A., Cohen,A., Bagarazzi,M.L., Higgins,T.J., Baine,Y., Ciccarelli,R.B., Ginsberg,R.S., Kim,J.J., MacGregor,R.R. and Weiner, D.B. Enhancement of cellular immune response in patients seropositive for HIV-1 utilizing DNA vaccines World AIDS Conference Proceedings. 2: 441-446, 1998.
  • Agadjanyan, MG.Wang, B.Nyland, SB.Weiner, DB.Ugen, KE. DNA plasmid based vaccination against the oncogenic human T cell leukemia virus type 1. Current topics in microbiology and immunology. 226: 175-92, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9479842
  • Agadjanyan, MG.Chattergoon, MA.Petrushina, I.Bennett, M.Kim, J.Ugen, KE.Kieber-Emmons, T.Weiner, DB. Monoclonal antibodies define a cellular antigen involved in HTLV-I infection. Hybridoma. 17(1) : 9-19, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9523233
  • Ugen,K.E., Boyer,J., Wang,B.,, Gluckman,S., Williams, W.V., Nyland,S., Carmack,B., Agadjanyan, M.G., Bagarazzi,M, Higgins,T., Coney,L., Ciccarelli,R.,, Ginsberg,R, MacGregor,R.R. and Weiner, D.B. Facilitated nucleic acid vaccination of humans with an HIV-1 expressing DNA boosts immune responses against the envelope glycoprotein Vaccines. 97(1) : 145-149, 1997.
  • Boyer,J.D., Ugen,K., Chattergoon,M., Tsai,A, Coney, L. and Weiner,D.B Induction of a cross reactive cellular immune response to HIV-1 by in vivo DNA inoculation Vaccines. 97(1) : 137-140, 1997.
  • Mahalingam, S.MacDonald, B.Ugen, KE.Ayyavoo, V.Agadjanyan, MG.Williams, WV.Weiner, DB. In vitro and in vivo tumor growth suppression by HIV-1 Vpr. DNA and cell biology. 16(2) : 137-43, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9052734
  • Agadjanyan,M.G., Trivedi,N., Kudchodkar,S., Bennett,M., Ugen,K.E. and Weiner,D.B. HIV-2 expression vector generates cross strain humoral and cellular anti-HIV-2 as well as anti-SIV immune responses Vaccines. 97(1) , 1997.
  • Ugen, KE.Srikantan, V.Goedert, JJ.Nelson, RP.Williams, WV.Weiner, DB. Vertical transmission of human immunodeficiency virus type 1: seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope glycoprotein. The Journal of infectious diseases. 175(1) : 63-9, 1997. http://www.ncbi.nlm.nih.gov/pubmed/8985197
  • Weiner,D.B., Ugen,K.E. and Williams,W.V. Methods and compositions for diagnosing and treating certain HIV infected patients Biotechnology Advances. 15: 438, 1997.
  • Wang, B.Dang, K.Agadjanyan, MG.Srikantan, V.Li, F.Ugen, KE.Boyer, J.Merva, M.Williams, WV.Weiner, DB. Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site. Vaccine. 15(8) : 821-5, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9234524
  • Boyer, JD.Ugen, KE.Wang, B.Agadjanyan, M.Gilbert, L.Bagarazzi, ML.Chattergoon, M.Frost, P.Javadian, A.Williams, WV.Refaeli, Y.Ciccarelli, RB.McCallus, D.Coney, L.Weiner, DB. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature medicine. 3(5) : 526-32, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9142121
  • Boyer, JD.Ugen, KE.Chattergoon, M.Wang, B.Shah, A.Agadjanyan, M.Bagarazzi, ML.Javadian, A.Carrano, R.Coney, L.Williams, WV.Weiner, DB. DNA vaccination as anti-human immunodeficiency virus immunotherapy in infected chimpanzees. The Journal of infectious diseases. 176(6) : 1501-9, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9395361
  • Agadjanyan, MG.Trivedi, NN.Kudchodkar, S.Bennett, M.Levine, W.Lin, A.Boyer, J.Levy, D.Ugen, KE.Kim, JJ.Weiner, DB. An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV. AIDS research and human retroviruses. 13(18) : 1561-72, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9430248
  • Ugen, KE.Boyer, JD.Wang, B.Bagarazzi, M.Javadian, A.Frost, P.Merva, MM.Agadjanyan, MG.Nyland, S.Williams, WV.Coney, L.Ciccarelli, R.Weiner, DB. Nucleic acid immunization of chimpanzees as a prophylactic/immunotherapeutic vaccination model for HIV-1: prelude to a clinical trial. Vaccine. 15(8) : 927-30, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9234550
  • Boyer,J.D., Wang, B., Ugen,K.E., Srikantan,V., Gilbert,L., Kudchodkar,S., Javadian.A., Dang,K., Merva,M., McCallus, D., Ciccarelli,R., Carrano,R.A., Coney,L. and Weiner, D. B. Induction of humoral and cellular immune responses to HIV-1 in chimpanzees by in vivo DNA inoculation Vaccines. 96(1) : 51-54, 1996.
  • McCallus,D., Coney,L., Wang,B., Boyer,J., Pachuk,C., Higgins,T., Carrano,R., Sims,D., Ugen,K., Weiner,D.B. and Ciccarelli, R Facilitated DNA injection elicits specific anti-HIV immune responses in preclinical animal models Vaccines. 96(1) : 55-60, 1996.
  • Ugen,K.E., Boyer,J.D., Agadjanyan,M.G., BAng,B., Javadian,A., Coney,L, McCallus,D. Williams, W.V., Ciccarelli,R., Carrano,R. and Weiner,D.B. Site-specific humoral immune responses generated in chimpanzees after DNA inoculation with HIV-1 envelope expressing constructs Vaccines. 96(1) : 61-65, 1996.
  • Ugen,K.E., Fernandes,L., Wang,B, Weiner,D.B. and Williams, W.V. Retroviruses and Autoimmunity Microrganisms and Autoimmune Diseases. : 219-231, 1996.
  • Ayyavoo, V.Ugen, KE.Fernandes, LS.Goedert, JJ.Rubinstein, A.Williams, WV.Weiner, DB. Analysis of genetic heterogeneity, antigenicity, and biological characteristics of HIV-1 in a maternal transmitter and nontransmitter patient pair. DNA and cell biology. 15(7) : 571-80, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8756338
  • Boyer, JD.Wang, B.Ugen, KE.Agadjanyan, M.Javadian, A.Frost, P.Dang, K.Carrano, RA.Ciccarelli, R.Coney, L.Williams, WV.Weiner, DB. In vivo protective anti-HIV immune responses in non-human primates through DNA immunization. Journal of medical primatology. 25(3) : 242-50, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8892046
  • Cotropia, J.Ugen, KE.Kliks, S.Broliden, K.Broliden, PA.Hoxie, JA.Srikantan, V.Williams, WV.Weiner, DB. A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 12(3) : 221-32, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8673526
  • Ugen,K.E., Agadjanyan,M.G., Wang,B., Kudchodkar, S.,, Merva,M., Boyer,J.D., Li,F., Williams, W.V. and Weiner, D.B. Elicitation of immune responses on rodents after DNA inoculation with an HTLV-I envelope glycoprotein expressing construct: a model for vaccination efficacy Vaccines. 95(1) : 129-134, 1995.
  • Boyer,J.D., Wang,B., Ugen,K.E., Agadjanyan, M.G., Wang, B., Kudchodkar,S., Merva, M., Boyer, J.D., Li,F., Willimas, W.V. and Weiner, D.B. Induction of humoral and cellular immune response to HIV-1 in Cynomologous macaques and chimpanzees Vaccines. 95(1) : 99-104, 1995.
  • Ugen, KE. Vertical transmission of HIV-1 infection. Diagnosis and prevention. The Journal of the Florida Medical Association. 82(12) : 825-6, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8568507
  • Wang, B.Boyer, JD.Ugen, KE.Srikantan, V.Ayyaroo, V.Agadjanyan, MG.Williams, WV.Newman, M.Coney, L.Carrano, R. Nucleic acid-based immunization against HIV-I: induction of protective in vivo immune responses. AIDS. 9 Suppl A: S159-70, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8819582
  • Wang, B.Merva, M.Dang, K.Ugen, KE.Williams, WV.Weiner, DB. Immunization by direct DNA inoculation induces rejection of tumor cell challenge. Human gene therapy. 6(4) : 407-18, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7612698
  • Wang, B.Boyer, J.Srikantan, V.Ugen, K.Agadjanian, M.Merva, M.Gilbert, L.Dang, K.McCallus, D.Moelling, K. DNA inoculation induces cross clade anti-HIV-1 responses. Annals of the New York Academy of Sciences. 772: 186-97, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8546392
  • Wang, B.Boyer, J.Srikantan, V.Ugen, K.Gilbert, L.Phan, C.Dang, K.Merva, M.Agadjanyan, MG.Newman, M. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology. 211(1) : 102-12, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7645204
  • Ugen, KE.Wang, B.Ayyavoo, V.Agadjanyan, M.Boyer, J.Li, F.Kudchodkar, S.Lin, J.Merva, M.Fernandes, L. DNA inoculation as a novel vaccination method against human retroviruses with rheumatic disease associations. Immunologic research. 13(2-3) : 154-62, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7775806
  • Srikantan, V.Wang, B.Satre, MA.Ugen, KE.Dang, K.Scales, F.Godillot, AP.Williams, WV.Weiner, DB. Cloning and biological characterization of human single-chain Fv fragments that mediate neutralization of HIV-1. AIDS (London, England). 8(11) : 1525-32, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7848589
  • Prammer, KV.Boyer, J.Ugen, K.Shattil, SJ.Kieber-Emmons, T. Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies. Receptor. 4(2) : 93-108, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7524891
  • Ugen, KE.Von Feldt, JM.Weiner, DB.Ziegner, UH. Diagnosis and prediction of pediatric HIV-1 infection and AIDS: current status. Journal of clinical laboratory analysis. 8(5) : 309-314, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7807285
  • Wang, B.Merva, M.Dang, K.Ugen, KE.Boyer, J.Williams, WV.Weiner, DB. DNA inoculation induces protective in vivo immune responses against cellular challenge with HIV-1 antigen-expressing cells. AIDS research and human retroviruses. 10 Suppl 2: S35-41, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7865331
  • Williams, WV.VonFeldt, JM.Rosenbaum, H.Ugen, KE.Weiner, DB. Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution. Arthritis and rheumatism. 37(10) : 1468-78, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7945472
  • Agadjanyan, MG.Ugen, KE.Wang, B.Williams, WV.Weiner, DB. Identification of an 80-kilodalton membrane glycoprotein important for human T-cell leukemia virus type I and type II syncytium formation and infection. Journal of virology. 68(1) : 485-93, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8254759
  • Coney, L.Wang, B.Ugen, KE.Boyer, J.McCallus, D.Srikantan, V.Agadjanyan, M.Pachuk, CJ.Herold, K.Merva, M. Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo. Vaccine. 12(16) : 1545-50, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7879423
  • wang,B, Merva,M., Dang,K., Boyer,J., Ugen,K.E., LiVolsi,V.,, Wilson,D., Li,F., Schumacher,H.R.,, Williams,W.V. and Weiner,D.B. A novel system to evaluate DNA inocualtion techniques for induction of in vivo protection Vaccines. 94(1) : 83-90, 1994.
  • Sato, AI.Balamuth, FB.Ugen, KE.Williams, WV.Weiner, DB. Identification of CD7 glycoprotein as an accessory molecule in HIV-1-mediated syncytium formation and cellfree infection. Journal of immunology (Baltimore, Md. : 1950). 152(10) : 5142-52, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7513730
  • Ugen,K.E., Galetta,S.M., VonFeldt,J.M., McCallus,D.E., Williams,W.V. and Weiner,D.B. Ocular manifestations of HIV-1 infection The AIDS Reader. 4: 66-71, 1994.
  • Goedert,J.J., Robert-Guroff,M., Ugen,K., Weiner,D.B., Matthews,T., Drummond,J., Rubinstein,A., Rossi,P., Durda,P., Zwart, G., Goudsmit,J., Allain,J.P., Walsh,J., Blattner,W., Mathison,B. and Dublin,S. Perinatal transmission of HIV type 1: associations with maternal and anti-HIV serological reactivity AIDS Res. Hum. Retro. 10: 1125-1134, 1994.
  • Ugen,K.E.,Srikantan,V., Wang,B.,Goedert,J., Ziegner,U., Agadjanyan,M.G., Boyer,J.D., Cotropia,J.P., Williams,W.V. and Weiner,D.B. Vertical transmission of human retroviral infections: immunological parameters Arch of STD/HIV Research. 8: 285-292, 1994.
  • Soprano, DR.Gyda, M.Jiang, H.Harnish, DC.Ugen, K.Satre, M.Chen, L.Soprano, KJ.Kochhar, DM. A sustained elevation in retinoic acid receptor-beta 2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis. Mechanisms of development. 45(3) : 243-53, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8011556
  • Eaton, AM.Ugen, KE.Weiner, DB.Wildes, T.Levy, JA. An anti-gp41 human monoclonal antibody that enhances HIV-1 infection in the absence of complement. AIDS research and human retroviruses. 10(1) : 13-8, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7514015
  • D'Angelo, M.Chen, JM.Ugen, K.Greene, RM. TGF beta 1 regulation of collagen metabolism by embryonic palate mesenchymal cells. The Journal of experimental zoology. 270(2) : 189-201, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7964554
  • Wang,B., Ugen,K.E., Srikantan,V., Agadjanyan,V., Dang,K., Sato,A.I., Refaeli,Y., Boyer,J., Williams,W.V. and Weiner,D.B. Gene immunization: a novel method for vaccine development against HIV Vaccines. 93(1) : 143-150, 1993.
  • Ugen,K.E., Refaeli,Y., Ziegner,U., Agadjanyan,M.G., Satre,M., Srikantan,V., Wang,B., Sato,A., Williams,W.V. and Weiner,D.B. Generation of monoclonal antibodies against the amino region of gp120 that elicit antibody dependent cellular cytotoxicity Vaccines. 93(1) : 215-221, 1993.
  • Wang, B.Ugen, KE.Srikantan, V.Agadjanyan, MG.Dang, K.Refaeli, Y.Sato, AI.Boyer, J.Williams, WV.Weiner, DB. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America. 90(9) : 4156-4160, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8483929
  • Bhat, S.Mettus, RV.Reddy, EP.Ugen, KE.Srikanthan, V.Williams, WV.Weiner, DB. The galactosyl ceramide/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275. AIDS research and human retroviruses. 9(2) : 175-81, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8457384
  • Wang, B.Boyer, J.Srikantan, V.Coney, L.Carrano, R.Phan, C.Merva, M.Dang, K.Agadjanan, M.Gilbert, L. DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates. DNA and cell biology. 12(9) : 799-805, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8216851
  • Wang, B.Agadjanyan, MG.Srikantan, V.Ugen, KE.Hall, W.Kaplan, MH.Dang, K.Williams, WV.Weiner, DB. Molecular cloning, expression, and biological characterization of an HTLV-II envelope glycoprotein: HIV-1 expression is permissive for HTLV-II-induced cell fusion. AIDS research and human retroviruses. 9(9) : 849-60, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8257634
  • Agadjanyan,M.G.,, Ugen,K.E., Wang,B., Willimas,W.V. and Weiner,D.B. DNA inoculation with an HTLV-I envelope DNA construct elicits immune responses in rabbits Vaccines. 94(1) : 47-53, 1993.
  • Ugen,K.E., Goedert,J.J. and Weiner,D.B. Maternal antibodies against HIV-1 envelope glycoprotein: model to evaluate vertical transmission/potential vaccine efficacy Arch of STD/HIV Research. 7: 223-228, 1993.
  • VonFeldt,J.M., Ugen,K.E.,Weiner,D.B. and Williams, W.V. Bioactive peptides based on antibody structure Biomedical applications of biotechnology. 92(1) : 55-85, 1992.
  • Ugen,K.E., Goedert,J.J.,Boyer,J., Refaeli,Y.,Williams,W.V.,Willoughby,A., Landesman,S., Rubinstein,A, Kieber-Emmons,T., Berzofsky,J. and Weiner,D.B. Vertical transmission of HIV-1 infection:maternal humoral immune responses to gp120 and gp41 peptides Vaccines. 92(1) : 183-189, 1992.
  • Sato,A.I., Ugen,K.E., Williams,W.V., Perussia,B. and Weiner,D.B. Identification of two non-CD4 molecules important for HIV-1 mediated syncytium formation Vaccines. 92(1) : 223-228, 1992.
  • Von Feldt, JM.Kieber-Emmons, T.Weiner, DB.Ugen, KE.Williams, WV. Molecular structure and granulocyte/macrophage colony-stimulating factor activity. DNA and Cell Biology. 11(3) : 183-91, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1373625
  • Kieber-Emmons, T.Krowka, JF.Boyer, J.Ugen, KE.Williams, WV.Morrow, WJ.Weiner, DB. Immunological characteristics of the putative CD4-binding site of the HIV-1 envelope protein. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology. 60(4) : 187-194, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1388715
  • Laczkó, I.Hollósi, M.Urge, L.Ugen, KE.Weiner, DB.Mantsch, HH.Thurin, J.Otvös, L. Synthesis and conformational studies of N-glycosylated analogues of the HIV-1 principal neutralizing determinant. Biochemistry. 31(17) : 4282-4288, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1567873
  • Ugen, KE.McCallus, DE.Von Feldt, JM.Williams, WV.Greene, MI.Weiner, DB. Ocular tissue involvement in HIV infection: immunological and pathological aspects. Immunologic Research. 11(2) : 141-153, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1431423
  • Ugen, KE.Goedert, JJ.Boyer, J.Refaeli, Y.Frank, I.Williams, WV.Willoughby, A.Landesman, S.Mendez, H.Rubinstein, A. Vertical transmission of human immunodeficiency virus (HIV) infection. Reactivity of maternal sera with glycoprotein 120 and 41 peptides from HIV type 1. The Journal of Clinical Investigation. 89(6) : 1923-1930, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1601999
  • Cotropia,J.P., Ugen,K.E., Lambert,D., Ljunggren-Broliden,K., Kliks,S., Hoxie,J. and Weiner,D.B. Characterization of human monoclonal antibodies (HuMab) to the HiV-1 transmembrane (TM) gp41 protein Vaccines. 92(1) : 157-163, 1992.
  • Satre, MA.Ugen, KE.Kochhar, DM. Developmental changes in endogenous retinoids during pregnancy and embryogenesis in the mouse. Biology of reproduction. 46(5) : 802-10, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1591336
  • Osther, K.Wiik, A.Black, F.Skinhøj, P.Kellermann, G.Ugen, KE.Williams, WV.Weiner, DB. PASSHIV-1 treatment of patients with HIV-1 infection. A preliminary report of a phase I trial of hyperimmune porcine immunoglobulin to HIV-1. AIDS. 6(12) : 1457-1464, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1362878
  • McCallus, DE.Ugen, KE.Sato, AI.Williams, WV.Weiner, DB. Construction of a recombinant bacterial human CD4 expression system producing a bioactive CD4 molecule. Viral Immunology. 5(2) : 163-172, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1319711
  • Ugen,K.E., Perussia,B., Kamoun,M., Merva,M.J., Williams,W.V.,Nara,P.,Kieber-Emmons,T. and Weiner,D.B. Inhibition of HIV-1 cellular infection by immunologic reagents Vaccines. 91(1) : 115-121, 1991.
  • Kieber-Emmons,T., Ugen,K.E., Merva,M.J., Whalley,A., Morrow,W.J. Engineered peptides that mimic HIV-1 neutraliziing envelope structures Vaccines. 91(1) : 165-173, 1991.
  • Osther, K.Kellermann, G.Ugen, KE.Williams, WV.Weiner, DB. Protective humoral immune responses to the human immunodeficiency virus induced in immunized pigs: a possible source of therapeutic immunoglobulin preparations. Hybridoma. 10(6) : 673-683, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1816071
  • Mahalingam, M.Ugen, KE.Kao, KJ.Klein, PA. Functional role of platelets in experimental metastasis studied with cloned murine fibrosarcoma cell variants. Cancer Research. 48(6) : 1460-1464, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3345518
  • Ugen, KE.Mahalingam, M.Klein, PA.Kao, KJ. Inhibition of tumor cell-induced platelet aggregation and experimental tumor metastasis by the synthetic Gly-Arg-Gly-Asp-Ser peptide. Journal of the National Cancer Institute. 80(18) : 1461-1466, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3184195

Positions Held

  • Professor (Medical Microbiology and Immunology, UNIVERSITY of SOUTH FLORIDA 2005 - 2006)
  • Associate Professor (Medical Microbiology and Immunology, UNIVERSITY of SOUTH FLORIDA 2000 - 2005)
  • Assistant Professor (Medical Microbiology and Immunology, UNIVERSITY of SOUTH FLORIDA 1995 - 2000)
  • Research Assistant Professor (Pathology, UNIVERSITY OF PENNSYLVANIA 1994 - 1995)
  • Assistant Professor (Biology, UNIVERSITY OF TEXAS at SAN ANTONIO 1995 - 1995)
  • Research Associate (Pathology, UNIVERSITY OF PENNSYLVANIA 1991 - 1994)
  • Research Investigator (Immunology Program, The Wistar Institute 1989 - 1991)
  • Postdoctoral Fellow (Anatomy, Jefferson Medical College 1988 - 1989)
  • Postdoctoral Fellow (Pathology, UNIVERSITY OF FLORIDA 1986 - 1988)