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Jaya Padmanabhan, Ph.D.

Assistant Professor, College Of Medicine Molecular Medicine
  • Our lab is interested in determining the molecular mechanisms involved in neurodegeneration associated with Alzheimer's disease (AD). Specifically, we are examining the role of cell cycle regulatory proteins and inflammatory proteins in neuritic plaque and neurofibrillary tangle formation. Experimental systems include transgenic mice and in vitro cultured transformed cells and primary neurons. While aberrant cell cycle activation is a characteristic feature of cancer progression, deregulated expression of cell cycle proteins in terminally differentiated neurons leads to catastrophe. Our recent studies showed that amyloid precursor protein (APP), which is associated with Alzheimer's disease may play a role in cancer progression. We are currently performing experiments to establish a correlative link between neurodegeneration and oncogenesis.
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Krishna Reddy

Graduate Research Assistant, College Of Medicine Molecular Medicine
  • The general interest of our lab focuses on the process of palmitoylation, a post-translational lipid modification that plays an important role in stability and trafficking of several important proteins such as Ras, as well as other proteins responsible for a variety of human diseases. My research combines structural bioinformatics and molecular biology in order to understand the DHHC palmitoyltransferase family. In particular, I aim to elucidate the structural mechanisms and identify novel functional regions in this family of proteins.


Sarah Fontaine, PhD

College Of Medicine Molecular Medicine