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JayaPadmanabhan

Jaya Padmanabhan, Ph.D.

Assistant Professor, College Of Medicine Molecular Medicine
  • Our lab is interested in determining the molecular mechanisms involved in neurodegeneration associated with Alzheimer's disease (AD). Specifically, we are examining the role of cell cycle regulatory proteins and inflammatory proteins in neuritic plaque and neurofibrillary tangle formation. Experimental systems include transgenic mice and in vitro cultured transformed cells and primary neurons. While aberrant cell cycle activation is a characteristic feature of cancer progression, deregulated expression of cell cycle proteins in terminally differentiated neurons leads to catastrophe. Our recent studies showed that amyloid precursor protein (APP), which is associated with Alzheimer's disease may play a role in cancer progression. We are currently performing experiments to establish a correlative link between neurodegeneration and oncogenesis.
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BoskoStojanovski

Bosko Stojanovski

Graduate Research Assistant, College Of Medicine Molecular Medicine
  • Heme Biosynthesis
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TapanBagui

Tapan Bagui, PHD

College Of Medicine Molecular Pharmacology & Physiology
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