Obesity, Diabetes & Aging

Facts About Monkeys

Obesity, in Monkeys, as in Humans:

  • Develops frequently in middle-age and older monkeys, just as it does in humans!
  • Is NOT experimentally induced
  • Occurs even when eating only a “healthy” diet
  • Resembles fully the obesity of middle-aged humans

Diabetes, in Monkeys, as in Humans:

  • Frequently develops in overweight monkeys just as it does in humans
  • Is treated clinically using the same drugs and methods as used in patients
  • Progresses in severity to manifest all of the complications of diabetes that are seen in patients

Metabolic Syndrome in Monkeys, just as in Humans:

  • Includes all of the characteristics of pre-diabetes and pre-cardiovascular disease shared in common by humans and monkeys, specifically:
  • Excess body fat (mild to moderate to severe obesity)
  • Impaired glucose tolerance
  • Elevated serum triglycerides
  • Low HDL cholesterol
  • Hypertension

Non human primates provide uniquely outstanding opportunities to determine the likelihood of efficacy in humans and increase the likelihood of successful translation of new discoveries and developments to humans.

Aging in Monkeys, as in Humans, is associated with many of the same changes including:

  • Frailty
  • Skin changes
  • Weight changes
  • Cataracts
  • Impaired vascular reactivity
  • Dyslipidemia
  • Increased blood pressure

Other Features commonly seen in middle-aged humans and monkeys include:

  • Endometriosis
  • Menopause
  • Declining lean body mass
  • Many other features of normal and abnormal aging in humans also develop naturally in monkeys