Paul Shapshak, PhD

Biographical Sketch

Dr. Paul Shapshak received his BA from Harvard College (Biochemical Sciences), his PhD from Princeton University (Biochemical Sciences), and completed a two-year Fellowship at NIH ([NICHD] Molecular Biology). He joined the faculty at the University of South Florida in 2007 after spending 17 years at University of Miami Miller School of Medicine.

His areas of research include laboratory methods development, molecular virology, bioinformatics, NeuroAIDS, drug abuse, HIV evolution in the brain, HCV, and dementia. He received and participated in grants from NIH including NIDA, NIMH, NINDS, and NIGMS. He has international scientific interests and has had researchers at his laboratory from the USA, India, Japan, China, Venezuela, Columbia, Brazil, Cuba, Nicaragua, Russia, Czechoslovakia, and Sweden.

Dr. Shapshak serves on NIDA and other NIH study sections (since 1989). He is on the Editorial Boards of several journals including AIDS, Biological Procedures On-line, Frontiers in Biosciences, and Bioinformation. He is a founding member of several scientific organizations including the College of Problems in Drug Dependence and American Society for Virology.

Areas of Expertise

• Infectious Diseases and International Medicine
• Drug abuse, HIV and HCV risk, and AIDS progression
• Prevention of spread of viruses and AIDS
• Gene expression in neuropsychiatric disease: NeuroAIDS, Alzheimer’s disease
• siRNA and vectors in Biology and Medicine
• Nanotechnology in Biology and Medicine
• Bioinformatics, development of databases, and network analyses of Gene Expression in disease
• Laboratory measures of virus infections, NeuroAIDS, Alzheimer’s disease
• Transmission model and inactivation of HIV-1 and HCV
• HIV-1 and HCV replication and evolution

Current Research

Principal Investigator

Shapshak PAllergy, Immunology & Infectious Disease Signature Program, USF Health. (PI), Xu W (Co-PI)
siRNA HIV-1B Silencing in NeuroAIDS Patients.
Pilot Grant from the
4/1/2008-3/31/2009

Shapshak P, PI (Sub-contract)
Bioinformatics in Neurodegenerative Disease.
The parent grant PI is Dr. T. Kazic, Dept. of Computer Engineering and Computer Science, Univ. of Missouri, Columbia.
Community Deposit and Review of Biochemical Databases
9/1/2003-8/31/2008 RO1 Research Grant, (2RO1 GM056529 NIGMS)

Shapshak P (PI)
Gene Expression in HIV Associated Dementia Brain.
7/17/02-8/30/05. R21 Basic Research Grant (NIDA.)

Shapshak P (PI), Fenjves E, and Pastori R.
Ribozyme-AAV Targeted Presenilin-1 Reduction in Neurons.
10/1/01-9/30/02 RO3 Basic Research Grant (NIA)

Shapshak P (PI), et al.
Replication of HIV in Brain Cell Cultures.
9/1/1993-8/31/1999, RO1 Basic Research Grant, renewed, (NIDA.)

Shapshak P (PI), McCoy C, Duncan R, et al.
Cocaine/cocaethylene/HIV in African-American Women.
07/15/1992 – 06/30/1998. RO1 Basic Research Grant, (NIDA.)

Co-Principal Investigator

Colón, HM PhD (Principal Investigator), Shapshak P (Consultant)
Drug Preparation Materials to Reduce HIV/HCV Transmission.
8/15/2005 thru 11/1/2006, 1 R21 DA018600

Eddy Rios-Olivares, PhD, MPH. (Principal Investigator), Shapshak P (Consultant)
HIV and Substances of Abuse.
08/01/2004 thru 11/1/2006 2G12RR03035

Page JB(PI) and Shapshak P (Co-PI), et al,
HIV Infection Potential in IDU-related Injection Materials.
7/1/00-6/30/04. RO1 Research Grant, (NIDA.)

Goodkin K. (Principal Investigator), Shapshak, P, et al.
AIDS and Aging: Indexes of Progression.
8/1/04-10/31/04, RO1 Research Grant, (NIMH.)

Petito C (PI) and Shapshak P, et al,
HIV Brain Sanctuary.
9/1/99-8/31/04. RO1 Research Grant, (NINDS)

Goodkin, K. (Principal Investigator), Shapshak, P, et al.
AIDS and Aging: Indexes of Progression.
8/1/98-7/31/03, RO1 Research Grant, (NIMH)

Kumar M (PI) and Shapshak P, et al,
AIDS in India: HIV-1 and HIV-2.
9/1/01-12/31/02. RO1 Research Grant (NINDS)

Goodkin, K. (Principal Investigator), Shapshak, P, et al.
The Impact of a Bereavement Support Group for Women with HIV Infection,
4/1/97-3/31/02, RO1 Research Grant, (NIMH.)

Petito C (PI) and Shapshak P, et al,
Neuropathogenesis of HIV Encephalitis.
9/1/96-8/31/01. RO1 Research Grant, (NINDS.)

Weiss S. [PI] and Shapshak P (Virology Director)
Behavioral Interventions for Women with AIDS.
12/1/97-6/30/99, supplement to RO1 Research Grant (NIMH)

McCoy CB (PI) and Shapshak P (Virology/Immunology Core Director)
HIV/Risk Reduction within Drug Injecting Networks.
6/1/95-5/31/98. RO1 Research Grant, (NIDA)

Selected Publications

Levine AJ, Service S, Miller EN, Reynolds SM, Singer EJ, Shapshak P, et. al. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults. American Journal of Medical Genetics: Part A, in press, 2013

Fogel GB, Lamers SL, Levine AJ, Valdes-Suerias M, Hinkin C, McGrath MS, Shapshak P, Singer EJ. Factors related to HIV-associated neurocognitive impairment differ with age. HIV Medicine, in press, 2013

Levine AJ, Singer EJ, Sinsheimer JS, Hinkin CH, Papp J, Dandekar S, Giovanelli A, Shapshak P. Host genetic, behavioral, and demographic factors in HIV-associated dementia. Neurobehavioral HIV Medicine, in press, 2013

Chiang MC, Barysheva M, McMahon KL, de Zubicaray GI, Johnson K, Montgomery GW, Martin NG, Toga AW, Wright MJ, Shapshak P, Thompson PM. Gene network effects on brain microstructure and intellectual performance identified in 472 twins. J Neurosci. 2012 Jun 20; 32(25): 8732-45. PMID: 22723713. PMCID: PMC3420968

Levine AJ, Sinsheimer JS, Bilder R, Shapshak P, Singer EJ. (2011) functional polymorphisms in dopamine-related genes: Effect on neurocognitive functioning in HIV+ adults. Journal of Clinical and Experimental Neuropsychology, DOI:10.1080/13803395.2011.623118

Shapshak P, Duncan R, Kangueane P, Somboonwit C, Sinnott J, Commins D, Singer E, Levine E. HIV-associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis) Bioinformation 2011; 6(5):183-186

Shapshak P, Duncan R, Duran EM, Farinetti F, Minagar A, Commins D, Rodriguez H, Chiappelli F, Kangueane P, Levine AJ, Singer E, Somboonwit C, Sinnott JT. Gene expression for HIV-associated dementia and HIV encephalitis in microdissected neurons 1: preliminary analysis. Neurobehavioral HIV Medicine 2011; 3:53-78

Shapshak P, Chiappelli F, Somboonwit C, Sinnott JT. The influenza pandemic of 2009: Lessons and implications. Mol Diag & Ther Apr 1 2011; 15(2):63-81

Barkhordarian A, Iyer N, Shapshak P, Somboonwit C, Sinnott J, Chiappelli F. Influenza 1009 pandemic: Cellular immune-mediated surveillance modulated by TH17 & Tregs. Bioinformation Mar 2 2011; 6(1):39-40

Chiappelli F, Somboonwit C, Sinnott JT, Shapshak P. Influenza 2009 Pandemic: Immunology. Bioinformation Mar 2 2011; 6(1):39-40

Sowmya G, Shamini G, Sathyanarayanan A, Sakharkar M, Mathura V, Rodriguez H, Levine AJ, Singer E, Commins D, Somboonwit C, Sinnott JT, Siddhu HS, Rajaseger G, Pushparaj PN, Kangueane P, Shapshak P. HIV-1 envelope accessible surface and polarity: clade, blood, and brain. Bioinformation Mar 22 2011; 6(2):48-56

Shamini G, Ravishandran M, Sinnott JT, Somboonwit C, Harcharan S, Sidhu HS, Shapshak P, Kangueane P. Structural inferences for Cholera toxin mutations in Vibrio cholerae. Bioinformation 2011; 6(1):1-9

Shapshak P, Kangueane P, Fujumura RK, Commins D, Chiappelli F, Singer E, Levine AJ, Minagar A, Novembre FJ, Somboonwit C, Nath A, Sinnott JT. Editorial NeuroAIDS Review. AIDS 2011; 25:123-141

Shapshak P, Somboonwit C, Sinnott JT, Commins D, Singer E, Levine AJ. Gene-chromosome locations of neuropsychiatric diseases. Bioinformation 2011; 7(7):366-368

Mohanapriya A, Nandogond S, Shapshak P, Kangueane U, Kangueane P. An HLA-DRB supertype chart with potential overlapping peptide binding function. Bioinformation 2010; 4(7):300-309

Selected Book Chapters

Fernandez F, Giunta B, Tan J, and Shapshak P. Neuropsychiatric aspects of prion disease. In Comprehensive Textbook of Psychiatry. Sadock, Sadock, and Ruiz (eds.), in press, 2007

Kangueane Pandjassarame, Meena Kishore Sakharkar, Francesco Chiappelli, Paul Shapshak. Designing HIV Peptide Vaccines: Rhetoric or Reality for NeuroAIDS, Chapter for: "The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment". K Goodkin MD PhD and P Shapshak PhD (eds.), ASM Press, in press, 2007

Shapshak Paul, Alireza Minagar, Pandjassarame Kangueane, Simon Frost, Sergei L, Kosakovsky Pond, Selene Sarate, Elyse Singer, Deborah Commins, Anne De Groot, Miguel Quinones-Mateu, Ernest Terwilliger. Blood and Brain HIV Strain Variation. Chapter for: "The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment". K Goodkin MD PhD and P Shapshak PhD (eds.), ASM Press, in press, 2007

Alireza Minagar and Paul Shapshak. HIV-associated Dementia: Clinical Features and Pathogenesis. In NEURO-AIDS, Alireza Minagar and Paul Shapshak (eds.), Nova Science Publ (Hauppauge, New York), 2006, in press

Alireza Minagar, Paul Shapshak, and J Steven Alexander. Pathogenesis of HIV-associated Dementia and Multiple Sclerosis: Role of Microglia and Astrocytes, in the role of Glia in Neurotoxicity, 2nd Edition, Michael Aschner and Lucio G Costa (eds.), CRC Press (Boca Raton, FL), 2005, Chapter 16, pp. 263-278

Selected Abstracts

Goodkin K, Asthana D, Shapshak P, Concha M, Khamis I, Lee D, Molina R, Frasca A, Zheng W, and O’Mellan S. Older Age and Immunological Measures among HIV-1 Infected Primary Spanish Speakers in the USA. In: Abstracts of 16th Annual Meeting of the Amer Neuropsychiatric Association, 2/25/05-3/1/05, Miami Beach, FL, poster session II, poster #11.

Paul Shapshak, Robert Duncan, Karl Goodkin, Avindra Nath, Jadwiga Turchen, Alireza Minagar, Solveig AM Shapshak, Wade Davis, Raman Seth, and Toni Kazic, Neuron model for cocaine abuse and HIV infection of brain (NeuroAIDS): gene expression in cultured human neurons exposed to cocaine and HIV-1 proteins gp120 and tat, The Third Symposium on the Functional Genomics of Critical Illness and Injury, NIH, April 21st and 22nd, Bethesda, 2005.

Shapshak P, Goodkin KG, Kazic T, Solveig AM Shapshak, and Nath A, Use of differing Microarray and bioinformatics technologies for gene expression in human neurons in culture and brain, 2005 NIDA International Forum: linking drug abuse and HIV/AIDS Research, June 17th -20th Orlando, FL 2005

Shapshak P, Goodkin KG, Duncan R, Nath A, Turchin J, Solveig AM Shapshak, Davis W, Kangueane P, Duran EM, Ziegler F, Minagar, Seth R, and Kazic T, Gene expression in human neurons in culture and brain. Use of differing Microarray and Bioinformatics technologies, 11th SNIP Conference, April 6th -10th , 2005, Clearwater, Florida.

Apple Lewis and P. Shapshak, HIV Risk in Drug Abuse Paraphernalia, 2004 Annual Biomedical Research Conference for Minority Students (ARBCMS), Hyatt Regency Dallas, Dallas, Texas, November 11th – 13th, 2004.

Eric Amaro and P. Shapshak, Apoptosis in astrocyte and neuroblastoma cell cultures: an in vitro model for Alzheimer’s disease, 2004 Annual Biomedical Research Conference for Minority Students (ARBCMS), Hyatt Regency Dallas, Dallas, Texas, November 11th – 13th, 2004.

P Shapshak, Invited Chair: International Symposium on Bioinformatics & Cybernetics, Orlando, Florida, July 14-18th, 2004 Brain gene expression (8 papers in chaired Symposium)

P Shapshak, Robert Duncan, Alireza Minagar, Karl Goodkin, Elda M. Duran, Avindra Nath, Jadwiga Turchan, Wade Davis, Raman Seth, and Toni Kazic, Gene expression methods in NeuroAIDS, Harvard University Channing Laboratories Statistics Society, May 2004.

P Shapshak, Robert Duncan, Alireza Minagar, Karl Goodkin, Elda M. Duran, Avindra Nath, Jadwiga Turchan, Wade Davis, Raman Seth, and Toni Kazic, The use of Bioinformatics for Gene expression studies in NeuroAIDS, NIMH 10th Annual Human Brain Project Conference, April 26th - 27th 2004

P Shapshak, Robert Duncan, Alireza Minagar, Raman Seth, and Toni Kazic, Gene expression in NeuroAIDS, International Neurovirology Society Conference, Baltimore, MD 2004

Shapshak Paul, Brain Gene Expression Studies In Dementia: Drug Abuse, HIV, and Amyloid, 3rd International Differential Gene Expression Symposium, Vanderbilt University School of Medicine, Oct 12-15th, 2002.

P Shapshak, Invited Chair: International Symposium on Bioinformatics & Cybernetics, Orlando, Florida, July 14-18th, 2002. (5 papers in chaired Symposium)

Torres-Munoz J, Shapshak P, Polavarapu G, Bowman M, and Petito CK, Gene expression in AIDS cerebral cortex, Int. Neurovirol. Meeting, Düsseldorf, Germany, June 11-19, 2002.

P. Shapshak, R. Duncan, J.B. Page, New Real Time PCR method for ultrasensitive quantification of HIV RNA in n/s, paraphernalia, and wash waters from shooting galleries in Miami, College of Problems in Drug Dependence, Quebec, CN, June 15th-19th, 2002.

P Shapshak, HIV evolution and NeuroAIDS, Gordon Conference on Bioinformatics, New Hampshire, August 2001.

C. McCoy, P. Shapshak, R. Duncan, F. Chiappelli, L. Metsch, and JB Page, Survival analysis and laboratory measures within a homogeneous cohort of Drug Abusers, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

J.B. Page, P. Shapshak, R. Duncan, E. Bandstra, and C. McCoy, Cocaine/Cocaethylene detection concordance: hair analysis vs. Urine Toxicology vs. Self-Report, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

P. Shapshak, R. Duncan, R. Kuljis, A. Minagar, P. Alcabes, R. Fujimura, R. Stewart, P. Rodriguez de la Vega, K. Goodkin, and C.K. Petito, Drug Abuse and AIDS Brain: Unexpected expression of neuronal Nitric Oxide Synthase, Interferon Gamma, TNF-alpha, and Il-4, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

R K Fujimura, I Khamis, P Shapshak, and K Goodkin, A Method for Regional Comparison of the Ratio of Regulatory mRNA to Structural RNA of HIV-1 in Infected Human Brain, American Society of Biochemistry and Molecular Biology, Orlando, FL, March 31st to April 4th, 2001.

A. Minagar, P. Shapshak, M Heyes, WA Sheramata, R. Fujimura, R. Ownby, K. Goodkin, and C. Eisdorfer, Microglia and astrocytes in NeuroAIDS, Alzheimer’s Disease, and Multiple Sclerosis, Miami Symposium in Biotechnology, Miami Beach, Florida, 2001.

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