USF Hepatitis C Evaluation and Technical Assistance Center

Charurut Somboonwit, MD, FACP

Associate Professor of Medicine, Division of Infectious Disease & International Medicine
Director of Communicable Diseases, Hillsborough County Health Department

Biographical Sketch | Areas of Expertise | Current Research | Publications

MD, Srinanakharinwirot University, Bangkok, Thailand
Residency, Internal Medicine, State University of New York at Brooklyn: Affiliated Program, St. John’s Episcopal Hospital, Far Rockaway, New York,
Fellowship, Infectious Disease, University of South Florida, College of Medicine
Contact Information
Phone: (813) 844-4187
FAX: (813) 844-7605

Biographical Sketch

Dr. Somboonwit is board certified in Internal Medicine and Infectious Diseases. After completion her fellowship in infectious diseases in 2003, she joined the Polk County Health Department. While she remained active in teaching as a clinical faculty, she was responsible for HIV care in a large rural HIV clinic in central Florida. She joined University of South Florida full time in 2006. In her current position as an Assistant Professor of Medicine, she also serves as Communicable Disease Director and Clinical Research Director for the Hillsborough Health Department. (link will open in new window)

Dr. Somboonwit is active in teaching. She currently serves as faculty of the Florida AIDS Education and Teaching Center; and she co-chairs the Scholarly Concentration in Research for Medical Students. She is a member of the Gold Humanism Society and a lifetime member of Leadership Florida. Most recently Dr. Somboonwit was elected to faculty membership of the Alpha Omega Alpha society.

Areas of Expertise


Current Research

A Pilot, Randomized, Controlled Study to Evaluate the Safety and Efficacy of Raltegravir versus NRTIs as a Backbone in HIV-Infected Patients Switched from a Stable Boosted PI Regimen. (Merck-IISP) (2008-present)

HIV and Cardiovascular Risks in an Urban Setting a retrospective study for cardiovascular risk factors prevalent among HIV positive patients receiving care in an urban Health Department located in Hillsborough County, FL. (2007-present)

Pilot Study for a Multisite HIV/AIDS Clinical and Resource Use Data (John Hopkins University) (2006-present)

A Phase III, Randomized, Double-Blind Study of TMC278 25 mg once daily in Combination with a Fixed Background Regimen Consisting of Tenofovir Disoproxil Fumarate and Emtricitabine in Antiretroviral-Naive HIV-1 Infected Subjects. (Tibotec (TMC278-209)) (2008-present)

A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Ritonavir-Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL) Each Administered With a Background Regimen in HIV-1 Infected, Antiretroviral Treatment-Experienced Adults. (Gilead (GS-US-183-0130)) (2008-present)

Vicriviroc in Combination Treatment With an Optimized ART Regimen in HIV-Infected Treatment-Experienced Subjects (VICTOR-E4) (2006-present)

Pilot Study for a Multisite HIV/AIDS Clinical and Resource Use Data. Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Two- Stage Study to Assess the Efficacy and Safety of Crofelemer 125mg, 250mg, and 500mg Orally Twice Daily for the Treatment of HIV-Associated Diarrhea [ADVENT TRIAL] (2006-present)

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of a Novel CCR5 Antagonist, UK-427,857, in Combination with Optimized Background Therapy Versus Optimized Background Therapy Along for the Treatment of Antiretroviral-Experienced HIV-1 Infected Subjects. Pfizer A4001027. (2005-present)

A randomized, controlled, partially blinded Phase IIb dose-finding trial of TMC125, in HIV-1 infected subjects with documented genotypic evidence of resistance to currently available NNRTIs and with at least three primary PI mutations. [TMC125-C223]

A Phase IIb, Randomized, Partially Blinded, Dose-Finding Trial of TMC278 in Antiretroviral Naïve HIV-1 Infected Subjects. [TMC278-204] (2005-present)

Disease Progression and Health Change Patterns among HIV-positive Patients at the Hillsborough County Health Department.

A Study to Evaluate the Efficacy of Quadrivalent HPV (Types 6, 11, 16, and 18) L1 Virus-Like Particle (VLP) Vaccine in Reducing the Incidence of HPV 6-, 11-, 16-, and 18-Related External Genital Warts, PIN, Penile, Perianal and Perineal Cancer, and the Incidence of HPV 6-, 11-, 16-, and 18-Related Genital Infection in Young Men.


Somboonwit C, Kurtyka D, Velez AP. Abacanvir and lamivudine combination. Expert Opin Drig Metabl Toxicol. 2009 Dec 5(12):1599-606.

Shapshak P, Somboonwit C, Drumright LN, Frost S DW, et al. Molecular and Contextual Markers of HCV and Drug Abuse.  Mol Diag and Ther, in press, 2009.

Shapshak P, Chiapelli F, Somboonwit C, Sinnott JT.  Containing the Influenza Pandemic of 2009: Lessons and Implications.  Mol Diag and Ther, in progress, 2009.

Castillo E, Somboonwit C, Sinnott JT, Shapshak P.  West Nile Virus Review, in progress, 2009.

Shapshak P, Duncan R, Duran EM, Ziegler F, Minagar A, Cummins D, Levine AJ, Singer E, Somboonwit C, Chiappelli F, Sinnott JT.  Gene Chromosomal Organization and Gene Expression in Neurons Microdissected from Basal Ganglia from Patients with HAD and HIVE.  Bioinformation, in progress, 2009.

Somboonwit C, Tash K, Donovan FM, Houston SH. Infectious Complications of Solid Organ Transplantation. Infection in Medicine. In press.

Giunta B, Somboonwit C, Nikolic WV, Rrapo E, Tan J, Shapshak P, Fernandez F.
Psychiatric implications of hepatitis-C infection.  Crit Rev Neurobiol. 2009;19(2-3):79-118.

Somboonwit C, Donovan F. St. Louis Enchaphalitis. Emedicine. Epub 2009 Jan 29. Found at:

Gompf S, Somboonwit C. Rabies. October 3, 2008. Found at:

Shapshak P, Somboonwit C, Francesco Chiappelli, Deborah Commins, Elyse Singer, Andrew J. Levine, Alireza Minagar, Andras J. Pellionisz.  Molecular Epigenetics, Chromatin, and NeuroAIDS/HIV: Translational Implications.  Bioinformation. 2008;3(1):53-7. Epub 2008 Oct 7.  Found at:

Shapshak P, Tellinghuisen T, Scott WK, Duncan R, McCoy C, Page JB, Somboonwit C, Giunta B, Fernandez F. Molecular Mechanisms in HCV and Drug Abuse. (accepted 2008)

Hamilton K, Somboonwit C, Haight D. Surviving and Understanding Meningitis. ABC News On-line. January 29, 2007. Found at:

Emmanuel SU, Goldstein-Hart C, Somboonwit C, Haight DO. Salmonella meningitis: Possible association with turtle. Epi Update, a publication of the Florida Department of Health, Bureau of Epidemiology. January 27, 2006.

Rungruanghiranya S, Somboonwit C, Kanchanapoom T.J. Acinetobacter Infection in the Intensive care Unit. Infect Dis Antimicrobial Agents. 2005;22:77-92.

Nadler JP, Wills T, Somboonwit C. Anemia prevalence and associated risk factors in a single-center ambulatory HIV clinical cohort. AIDS Reader. June 2004;14(6): 305-10.

Haight DO, Somboonwit C, Degryse A. West Nile Viruses: Clinical and Diagnostic Considerations. Clinical Microbiology Newsletter. October 2003;25(19):149-51.

Somboonwit C, Greene JN. Diagnostic Methodologies for Diagnosis of Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Patient. Seminars in Respiratory Infections. June 2002;17(2):151-7.

Book Chapters

Somboonwit C, Menezes LJ.  Kaposi’s Sarcoma (KS).  In J Beal, J Orrick, K Alfonso, M Rathore (eds.), HIV/AIDS Primary Care Guide.  Norfolk, CT. Crown House Publishing Company LLC, 2006.  Pp. 369-375.

Somboonwit C.  Infections in Lung Cancer Patients.  In Greene JN (ed.), Infections in Cancer Patients.  New York: Marcel Dekker, 2004.  Pp. 187-197.

Somboonwit C, Poklepovic A, Irvine L, Sinnott JT. Infectious disease aspects of viral hemorrhagic fever. In: Soule BM ed. The American Practitioner in Infection Control. St. Louis: Mosby-Year Book, Inc., 2004.
Somboonwit C. Infections in Lung Cancer Patients. In Greene JN (ed.), Infections in Cancer Patients. New York: Marcel Dekker, 2004. Pp. 187-197.

Somboonwit C. Infections in Head and Neck Cancer Patients. In Greene JN (ed.), Infections in Cancer Patients. New York: Marcel Dekker, 2004. Pp. 177-185.

Somboonwit C. Viral Hemorrhagic Fever. In APIC Text of Infection Control & Epidemiology. Washington, DC: Association for Professionals in Infection Control and Epidemiology, 2005. Pp. 90(1-11).


Menezes L, D’Souza KR, D’Souza KM, Somboonwit C, Amin S, Sinnott J. A socio-historical construction of the AIDS epidemic in India. Abstract: MOPE0724. Presentation at the XVI International AIDS Conference. Toronto, 2006.

Nadler JP, Wills TS, Somboonwit C, et al. Anemia prevalence among HIV patients: antiretroviral therapy and other risk factors: abstract 1151.  2nd IAS Conference on HIV Pathogenesis and Treatment, Paris, 2003.

Somboonwit C, Greene JN, Haight DO.  Pulmonary Penicilliosis Marneffei in a Cancer Patient without Endemic Area Exposure:  A Case Report.  Focus on Fungal Infections. Phoenix, 2002.