Research

Welcome to The University if South Florida Emergency Medicine Research Section

The research division has embarked on a collaborative, multi-disciplinary approach to emergency medicine research. We have been party to multiple inter-departmental research projects, as well as those solely based in the E.D. We have recently formed the brain injury research team with the departments of Neurology and Neurosurgery to further our efforts. In addition to our many industry-sponsored projects, we have submitted numerous grant proposals through the NIH and the WHO. Please find a list of projects below.

USF-TGH ProCESS Team

List of active and upcoming industry sponsored ED based projects

• Multicenter observational study of efficacy of intranasal hydromporphone for treatment of pain due to trauma
• PRIME multicenter observational study of ability of an 80 lead ECG to determine existence of occult coronary syndromes
• Process multicenter observational sepsis study
• CRUSADE registry
• Incidence of Neurologic Emergencies within the Florida NETT (Neurological Emergencies Treatment Trials) Network
• A prospective, multi-centre, observational study involving patients hospitalized with complicated skin and soft tissue infections (cSSTI) for IV antibiotic treatment.
• ProCESS (Protocolized Care for Early Septic Shock)
• The BEACON (Best Expert Agreement for Care of Occult MI Nationally) Patient Registry.
• Validity of High Fidelity Simulation in E. M. Resident Clinical Evaluation.
• The Increased Flow Utilizing Subcutaneously - Enabled Pediatric Rehydration II (INFUSE-Pediatric Rehydration II) Study: Subcutaneous Rehydration with Recombinant Human Hyaluronidase (hylenex) compared to Intravenous Rehydration in Infants and Young children With Mild to Moderate Dehydration.
• The SCRAPE Study
• A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects With Acute Coronary Syndrome: Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA-CER).
• Bio-Availability P.O. vs. I.V – A study of ED Physician Practice Patterns
• THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NHYA Class III/IV Cardiac Patient Evaluation.
• Treatment of Post Concussion Symptoms – A Three Center Pilot Study
• Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

Recently completed trials

• Randomized, Double-Blind, Placebo Controlled, Multi-Centre, Parallel Groups Confirmatory Efficacy and Safety Trial of Activated Recombinant Factor VII (NovonSeven®/Niastase®) in Acute intracerebral Hemorrhage Phase3a trial.
• ADHERE registry EM module
• Phase 4 trial to evaluate the pharmacokinetic profile of intravenous daptomycin and a comparison of the safety and efficacy of daptomycin versus comparator in the treatment of adult patients with renal impairment and complicated soft tissue infections. (complete)
• Efficacy and safety of drotrecogin Alfa (activated) in adult patients with early stage severe epsis. (complete)
• A prospective, randomized, double-blind, placebo controlled, dose ranging, multi-center study of the safety and efficacy of three days or continuous infusion of GR270773 in the treatment of suspected gram negative severe sepsis in adults. (complete)