Radouil Tzekov, Ph.D.

Assistant Professor, College Of Medicine Ophthalmology

College Of Medicine Ophthalmology

Adjunct Assistant Professor, Ophthalmology, USF

Senior Research Scientist III, Vision Research Program in neurodegenerative diseases, The Roskamp Institute

Contact Info 12901 Bruce B. Downs Blvd.
MDC 21
Tampa, FL 33612

Academic Email: rtzekov@health.usf.edu

Academic Phone: (813) 974-1530


  • Certificate, Clinical Sciences, PERI, 2008
  • Postdoctoral fellowship, Visual function testing, Smith-Kettlewell Eye Research Institute, 2002
  • Postdoctoral fellowship, Visual function testing, Stanford University, 2001
  • Postdoctoral fellowship, Applied Vision Research, Retina Foundation of the SW, 2000
  • Postgraduate fellowship, Applied Vision Research, City University, 1997
  • PhD, Ophthalmology, Medical University, 1996
  • MD, Medicine, Medical Academy, 1984

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Neurodegenerative Disease

Research Interests

  • Clinical visual electrophysiology and psychophysics; traumatic brain injury; retinal degenerative diseases; visual function in neuro-degenerative disease.


  • American Association for the Advancement of Science (AAAS) (Member, 2001 - Present)
  • New York Academy of Sciences (NYAS) (Member, 2001 - Present)
  • International Society for Clinical Electrophysiology of Vision (ISCEV) (Member, 1998 - Present)
  • Association for Research in Vision and Ophthalmology (ARVO) (Member, 1997 - Present)

Recent Publications

  • Tzekov, R.Quezada, A.Gautier, M.Biggins, D.Frances, C.Mouzon, B.Jamison, J.Mullan, M.Crawford, F. Repetitive Mild Traumatic Brain Injury Causes Optic Nerve and Retinal Damage in a Mouse Model. Journal of neuropathology and experimental neurology. , 2014. http://www.ncbi.nlm.nih.gov/pubmed/24607965
  • Lei, L.Tzekov, R.McDowell, JH.Smith, WC.Tang, S.Kaushal, S. Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Experimental eye research. 112: 57-67, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23603319
  • Byrne, M.Tzekov, R.Wang, Y.Rodgers, A.Cardia, J.Ford, G.Holton, K.Pandarinathan, L.Lapierre, J.Stanney, W.Bulock, K.Shaw, S.Libertine, L.Fettes, K.Khvorova, A.Kaushal, S.Pavco, P. Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 29(10) : 855-64, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24180627
  • Tzekov, R.Mullan, M. Vision function abnormalities in Alzheimer disease. Survey of ophthalmology. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24309127
  • Zheng Q., Ren, Y.,Tzekov, R., Zhang, Y.Chen, B.Hou, J.Zhao, C.Zhu, J.Zhang, Y.Dai, X.Ma, S.Li, J.Pang, J.Qu, J.Li, W. Differential Proteomics and Functional Research following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis. PloS one. 7(8) : e44855, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22953002
  • Lei, L., Tzekov, R., Tang,, S.Kaushal, S. Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells. Molecular vision. 18: 103-13, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22275801
  • Meklenburg, J.Clancy, EA.Tzekov, R. Signal processing techniques for oscillatory potential extraction in the electroretinogram: automated highpass cutoff frequency estimation. Documenta ophthalmologica. Advances in ophthalmology. 125(2) : 101-11, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22777656
  • Kleinberg, TT.Tzekov, RT.Stein, L.Ravi, N.Kaushal, S. Vitreous substitutes: a comprehensive review. Survey of ophthalmology. 56(4) : 300-23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21601902
  • Tzekov, R.Stein, L.Kaushal, S. Protein misfolding and retinal degeneration. Cold Spring Harbor perspectives in biology. 3(11) : a007492, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21825021
  • Clemson, CM.Tzekov, R.Krebs, M.Checchi, JM.Bigelow, C.Kaushal, S. Therapeutic potential of valproic acid for retinitis pigmentosa. The British journal of ophthalmology. 95(1) : 89-93, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20647559
  • Akula, JD.Hansen, RM.Tzekov, R.Favazza, TL.Vyhovsky, TC.Benador, IY.Mocko, JA.McGee, D.Kubota, R.Fulton, AB. Visual cycle modulation in neurovascular retinopathy. Experimental eye research. 91(2) : 153-61, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20430026
  • Messias, A.Zrenner, E.Tzekov, R.McGee, D.Peters, T.Wilhelm, B.Baryluk, A.Kubota, R.Gekeler, F. Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats. Documenta ophthalmologica. Advances in ophthalmology. 120(2) : 165-74, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20012154
  • Tzekov, R., Lin, T., Zhang, KM., Jackson, B., Oyejide, A., Orilla, W.Kulkarni, AD.Kuppermann, BD.Wheeler, L.Burke, J. Ocular changes after photodynamic therapy. Investigative ophthalmology & visual science. 47(1) : 377-85, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16384988
  • Tzekov, R. Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates. Documenta ophthalmologica. Advances in ophthalmology. 110(1) : 111-20, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16249962
  • Brigell, M.Dong, CJ.Rosolen, S.Tzekov, R. An overview of drug development with special emphasis on the role of visual electrophysiological testing. Documenta ophthalmologica. Advances in ophthalmology. 110(1) : 3-13, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16249953
  • Kulkarni, AD.Kuppermann, BD.Tzekov, RT.Lin, T.Burke, JA. Vitreous surgery in pigmented rabbits using the new, noncontact wide-field viewing system. American journal of ophthalmology. 137(1) : 212-3; author reply 213, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14700687
  • Tzekov, RT., Serrato, A., Marmor, MF. ERG findings in patients using hydroxychloroquine. Documenta ophthalmologica. Advances in ophthalmology. 108(1) : 87-97, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15104171
  • Tzekov, RT., Gerth, C., Werner, JS. Senescence of human multifocal electroretinogram components: a localized approach. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 242(7) : 549-60, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15085352
  • Tzekov, RT, .Locke, KG., Hood, DC., Birch, DG. Cone and rod ERG phototransduction parameters in retinitis pigmentosa. Investigative ophthalmology & visual science. 44(9) : 3993-4000, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12939320
  • Marmor, MF.Serrato, A.Tzekov, R. Comparison of conventional ERG parameters and high-intensity A-wave analysis in a clinical setting. Documenta ophthalmologica. Advances in ophthalmology. 106(3) : 281-7, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12737506
  • Penrose, PJ., Tzekov, RT., Sutter, EE.Fu, AD.Allen, AW.Fung, WE.Oxford, KW. Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine. Retina (Philadelphia, Pa.). 23(4) : 503-12, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12972762
  • Serrato, A., Tzekov, R., Marmor, MF. The lens-coating agent and the electroretinogram. Documenta ophthalmologica. Advances in ophthalmology. 106(3) : 225-30, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12737498
  • Birch, DG.Hood, DC.Locke, KG.Hoffman, DR.Tzekov, RT. Quantitative electroretinogram measures of phototransduction in cone and rod photoreceptors: normal aging, progression with disease, and test-retest variability. Archives of ophthalmology. 120(8) : 1045-51, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12149058
  • Pham, RT., Tzekov, RT., Biesman, BS., Marmor, MF. Retinal evaluation after 810 nm Dioderm laser removal of eyelashes. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 28(9) : 836-40, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12269879
  • Tzekov, RT., Liu, Y., Sohocki, MM., Zack, DJ., Daiger, SP., Heckenlively, JR., Birch, DG. Autosomal dominant retinal degeneration and bone loss in patients with a 12-bp deletion in the CRX gene. Investigative ophthalmology & visual science. 42(6) : 1319-27, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11328746
  • Tzekov, RT.Sohocki, MM.Daiger, SP.Birch, DG. Visual phenotype in patients with Arg41Gln and ala196+1bp mutations in the CRX gene. Ophthalmic genetics. 21(2) : 89-99, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10916183
  • Yankov, E.Nakova, A.Tzekov, R. Spectral sensitivity of the visual system as revealed by evoked potentials in normal and anomalous trichomats. Acta physiologica et pharmacologica Bulgarica. 24(4) : 91-100, 1999. http://www.ncbi.nlm.nih.gov/pubmed/11098295
  • Arden, G.Wolf, J.Berninger, T.Hogg, CR.Tzekov, R.Holder, GE. S-cone ERGs elicited by a simple technique in normals and in tritanopes. Vision research. 39(3) : 641-50, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10341991
  • Weng, J.Mata, NL.Azarian, SM.Tzekov, RT.Birch, DG.Travis, GH. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell. 98(1) : 13-23, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10412977
  • Tzekov, R.Arden, GB. The electroretinogram in diabetic retinopathy. Survey of ophthalmology. 44(1) : 53-60, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10466588