PRESIDENT OF THE FACULTY 

2013-15

 

   

Javier Cuevas, PhD 

 

 

 

 

Academic Positions:  

 

1999-2005          Assistant Professor, Department of Pharmacology and Therapeutics, University of South

                       Florida College of Medicine, Tampa, FL.

2005-2006          Associate Professor, Department of Pharmacology and Therapeutics, University of South

                       Florida College of Medicine, Tampa, FL.

2006-2012      Associate Professor, Department of Molecular Pharmacology and Physiology, University

                       of South Florida College of Medicine, Tampa, FL.

2010               Interim Chair, Department of Pharmaceutical Sciences, University of South Florida

                       College of Medicine, Tampa, FL.

2011-2012      Associate Professor, Department of Pharmaceutical Sciences, University of South Florida

                       College of Pharmacy, Tampa, FL.

2012-present  Professor, Department of Molecular Pharmacology and Physiology, University of South

                        Florida College of Medicine, Tampa, FL.

2012-present  Associate Professor, Department of Pharmaceutical Sciences, University of South

                        Florida College of Pharmacy, Tampa, FL.

 

Education:  

 

1990    A.B.     Biology-Psychology                                     Dartmouth College, Hanover, NH

1995    Ph.D.   Molecular and Cellular Pharmacology        University of Miami School of Medicine, Miami, FL

1995-1996       Post-doctoral training                                  University of Queensland, Australia

                                                                                             Dept. of Physiology (D. Adams)

1996-1998       Post-doctoral training                                  University of California, San Diego

                                                                                             Department of Biology, (D. Berg)

 

 

Teaching Responsibilities: 

COURSES TAUGHT:

Undergraduate Medical:

At University of South Florida College of Medicine:

2011-present   Basic Medical Sciences Course 6 (BMS 6042). Prepared and delivered lectures on the pharmacology of the autonomic nervous system, and pharmacotherapy for hypertension, edematous states, angina, myocardial infarction and congestive heart failure.

Graduate Medical Sciences:  Teach in over 16 graduate courses.

2003-present   Systems Physiology and Pharmacology (GMS 6461).  Course director.  Developed course content. Prepared and delivered lectures on pharmacology of the autonomic nervous system, vasodilators, vasoactive peptides, diuretics and the molecular basis of vascular disease.

DOCTORAL DISSERTATIONS DIRECTED: (Chairman, Ph.D. Committees)

2002-2005       Hongling Zhang, Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Currently working as a scientist for the U.S. Food and Drug Administration.

2002-2005       Wayne I. Dehaven, Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Currently working as a scientist for the U.S. Food and Drug Administration.

2006-2009       Yelenis Herrera, Department of Molecular Pharmacology and Physiology,

University of South Florida College of Medicine, Currently working as a Postdoctoral Assistant UT Southwestern Medical Center, Department of Physiology, in the laboratory of Dr. Joyce Repa.

2007-present   Timetria Bonds, Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine

2010-present   Stephanie Hart-Hughes, USF Scholars in Patient-Oriented Research (SPOR) K30 Program.  Department of Molecular Pharmacology and   Physiology, University of South Florida College of Medicine

POSTDOCTORAL TRAINEES:

2002-2004       Emily G. Severance, Ph.D., Currently working as a research Assistant Professor in the Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD

2005-2009       Christopher Katnik, PhD.

OTHER EDUCATIONAL ACTIVITIES:

2002-present    Faculty Mentor, McNair Scholars Program, University of South Florida

2005-present    Faculty Mentor, Marc/U-STAR Scholars Program, University of South Florida

2010-present    Founder and Director of Medical Mission to Dilaire, Haiti.  Goal of medical mission is to provide educational opportunity to medical students

                         and medical residents in a rural, underserved, tropical environment.

 

 

Honors and Awards:

             

2006                Biotechnology Excellence Award, University of South Florida College of Medicine, Tampa, FL.

2008-2010       University of South Florida Leadership Institute

2008-2011       Dean’s Academic Performance Award, Recognition for outstanding contribution to the Mission of the College of Medicine, University of

                        South Florida College of Medicine, Tampa, FL.

 

 

Research:

 

Focus Areas:   1) Autonomic control of the heart; 2) Stroke

GRANT PROPOSALS FUNDED (since 2009):

2009-2011      “Synthesis and screening of sigma receptor ligands for stroke therapy at delayed time points.”  Co-Principal Investigator, PI Project 2

                        King Biomedical Research Program, State of Florida, ($ 764,174, total costs for two years; Project 2: $156,965, total cost for two years).

2009-2011       Effects of Afobasol on Calcium Handling in Neurons During IschemiaPrincipal Investigator, RF Pharmaceuticals Sarl, ($44,825, total

                        costs for one year).

2009-2011       Effects of Afobasol on Calcium Handling in Neurons and MicrogliaPrincipal Investigator, MDR Pharmaceutical Limited, ($85,298, total

                        costs for one year).

2010-2012       “Role of Calcium in Mediating c-HYD1 and HYD1 Induced Cell Death in Multiple Myeloma” Collaborator, Multiple Myeloma Research

                        Foundation, ($200,000, total costs for two tears; $13,982 sub award), Lori Hazlehurst, PI.

2011-2012       “Neuroprotective properties of Afobasol modeled in vitro” Principal Investigator, MDR Pharmaceutical Limited, ($93,767, total costs for one

                        year).

2011-2013       “Effects of Afobasol in Rat Model of Ischemic Stroke” Principal Investigator, MDR Pharmaceutical Limited, ($369,968.73, total costs for two

                        years).

2011-2013       "Molecular mechanisms of sigma receptor-mediated cytoprotection.” Principal Investigator, American Heart Association

                        Grant-In-Aid, Greater Southeastern Affiliate (11GRNT7990120; $165,000).

PUBLICATIONS:

Refereed journal articles (last 5 years):

1.        McCord, A.M., Cuevas, J., and Anderson, B. (2007). Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. DNA and Cell Biol. 26:657-663.

2.        Song, S., Song, S., Zhang, H., Cuevas, J., and Sanchez-Ramos, J. (2007). Comparison of neurons derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem Cells and Development 16:747-756.

3.        Herrera, Y., Katnik, C., Rodriguez, J.D., Hall, A.A., Willing, A., Pennypacker, K.R., and Cuevas, J. (2008). Sigma-1 receptor modulation of ASIC1a channels and ASIC1a-induced Ca2+ influx in rat cortical neurons. J. Pharmacol. Exp. Ther. 327:491-502.

4.        Pollock, V.V., Pastoor, T., Katnik, C., Cuevas, J. and Wecker, L. (2009). Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate a4b2 nicotinic receptor subunits at distinct stages of receptor formation and maturation.  Neuroscience 158:1311-1325.

5.        Hall, A.A., Herrera, Y., Ajmo C.T., Cuevas, J.*, Pennypacker K.R. (2009).  Sigma receptors suppress multiple aspects of microglial activation.  Glia 57:744-754. *corresponding author

6.        Ajmo, T.C., Collier, L.A., Leonardo, C.C., Hall, A.A., Green, S.M., Cuevas, J., Willing, A.E., Pennypacker, K.R. (2009). Blockade of adrenoreceptors inhibits the splenic response to stroke.  Exp. Neuro. 218:47-55.

7.        Zhang, H., Katnik, C. and Cuevas, J. (2009).  Sigma Receptor Activation Inhibits Voltage-Gated Sodium Channels in Rat Intracardiac Ganglion Neurons. IJPPP. 2:1-11

8.        Cortes-Salva, M.Y., Nguyen, B-L, Cuevas, J., Pennypacker, K.R., and Antilla, J.C. (2010) Copper-Catalyzed Cross Guanidinylation of Aryl Iodides: The Formation of N,N’-Disubstituted Guanidines. Organic Letters 12:1316-1319.

9.        Mari, Y., Katnik, C., and Cuevas, J. (2010). ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular calcium overload during ischemia and acidosis. Cell Calcium 48:70-82.

10.     Yanamandra, N., Buzzeo, R.W., Gabriel, M., Mari, Y., Beaupre, D.M., Cuevas, J.  (2011).  Tipifarnib-induced apoptosis in acute myeloid leukemia cells is dependent on Ca2+ influx through plasma membrane Ca2+ channels. J. Pharmacol. Exp. Ther. 337:636-643.

11.     Cuevas, J., Behensky, A. and Katnik, C. (2011). Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors. J. Pharmacol. Exp. Ther. 339:152-160.

12.     Cuevas, J., Rodriguez, A., Behensky, A. and Katnik, C. (2011).  Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors. J. Pharmacol. Exp. Ther. 339:161-172. 

PATENTS:

2005                Effective Treatment with Sigma Receptor Agonists Post-Stroke. USF Ref: 05A046PRC, U.S. patent pending.

2005                Screening for New Agents for Post-Stroke Treatment. USF-05B105, U.S. patent pending.

2009                Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins, United States Patent 7563595.

2010                N, N'-di-p-bromophenyl Guanidine Treatment for Stroke at Delayed Timepoints. 08A048PRWOUS, U.S. patent pending.

2011                Targeting Orai3 for cancer chemotherapy.  08B089PRC, Patent pending.

2011                Creation of ischemic penumbra on a chip.  Patent pending.

 

 

Service:

SCIENTIFIC ADVISORY BOARDS: 

2008-present               American Heart Association Greater Southeast Affiliate Research Committee

UNIVERSITY SERVICE:

2003-present               Faculty Advisor, McNair Scholars Program

2004-present               Faculty Advisor, Latino Medical Student Association

2005-present               Faculty Advisor, Marc/U-STAR Scholars Program

COMMUNITY SERVICE:

2009-present               Medical Mission to Dilaire, Haiti; Director

 

Faculty Council Goals: 

The next few years will pose significant challenges to USF Morsani College of Medicine as we adapt to the economic realities of decreased funding from state and federal sources and changes to healthcare reimbursement, while at the same time growing as an institution.  In addition, our faculty are being impacted by major changes, such as the structure of the curriculum, the manner in which we are evaluated by the administration, and the leadership organization of our college.  The USF MCOM Faculty Council needs to enhance participation of faculty, many of whom have become disengaged, and foster a culture of joint governance with the administration to influence the direction setting process.  Ultimately, the increased input from our talented faculty will enrich our college of medicine and improve faculty satisfaction.

 

September 2012