President of the Faculty 2013 - 15

Javier Cuevas, PhD 

Javier CuevasAcademic Positions:

1999-2005: Assistant Professor, Department of Pharmacology and Therapeutics, University of South
Florida College of Medicine, Tampa, FL.

2005-2006: Associate Professor, Department of Pharmacology and Therapeutics, University of South
Florida College of Medicine, Tampa, FL.

2006-2012: Associate Professor, Department of Molecular Pharmacology and Physiology, University 
of South Florida College of Medicine, Tampa, FL.

2010: Interim Chair, Department of Pharmaceutical Sciences, University of South Florida 
College of Medicine, Tampa, FL.

2011-2012: Associate Professor, Department of Pharmaceutical Sciences, University of South Florida
College of Pharmacy, Tampa, FL.

2012-present: Professor, Department of Molecular Pharmacology and Physiology, University of South
Florida College of Medicine, Tampa, FL.

2012-present: Associate Professor, Department of Pharmaceutical Sciences, University of South
Florida College of Pharmacy, Tampa, FL.

Education:

1990: A.B. Biology-Psychology Dartmouth College, Hanover, NH 

1995: Ph.D. Molecular and Cellular Pharmacology University of Miami School of Medicine, Miami, FL 

1995-1996: Post-doctoral training University of Queensland, Australia Dept. of Physiology (D. Adams) 

1996-1998: Post-doctoral training University of California, San Diego Department of Biology, (D. Berg)

Teaching Responsibilities:

Courses Taught:

Undergraduate Medical:

At University of South Florida College of Medicine:

2011-present Basic Medical Sciences Course 6 (BMS 6042). Prepared and delivered lectures on the pharmacology of the autonomic nervous system, and pharmacotherapy for hypertension, edematous states, angina, myocardial infarction and congestive heart failure.

Graduate Medical Sciences:  Teach in over 16 graduate courses.

2003-present Systems Physiology and Pharmacology (GMS 6461).  Course director.  Developed course content. Prepared and delivered lectures on pharmacology of the autonomic nervous system, vasodilators, vasoactive peptides, diuretics and the molecular basis of vascular disease.

Doctoral Dissertations Directed: (Chairman, Ph.D. Committees)

2002-2005: Hongling Zhang, Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Currently working as a scientist for the U.S. Food and Drug Administration.

2002-2005: Wayne I. Dehaven, Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Currently working as a scientist for the U.S. Food and Drug Administration.

2006-2009: Yelenis Herrera, Department of Molecular Pharmacology and Physiology,University of South Florida College of Medicine, Currently working as a Postdoctoral Assistant UT Southwestern Medical Center, Department of Physiology, in the laboratory of Dr. Joyce Repa.

2007-present: Timetria Bonds, Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine

2010-present: Stephanie Hart-Hughes, USF Scholars in Patient-Oriented Research (SPOR) K30 Program.  Department of Molecular Pharmacology and   Physiology, University of South Florida College of Medicine

Postdoctoral Trainees: 

2002-2004: Emily G. Severance, Ph.D., Currently working as a research Assistant Professor in the Stanley Division of Developmental Neurovirology,Johns Hopkins University School of Medicine, Baltimore, MD

2005-2009: Christopher Katnik, PhD.

Other Educational Activities:

2002-present: Faculty Mentor, McNair Scholars Program, University of South Florida

2005-present: Faculty Mentor, Marc/U-STAR Scholars Program, University of South Florida

2010-present: Founder and Director of Medical Mission to Dilaire, Haiti.  Goal of medical mission is to provide educational opportunity to medical students and medical residents in a rural, underserved, tropical environment.

Honors and Awards:

2006: Biotechnology Excellence Award, University of South Florida College of Medicine, Tampa, FL.

2008-2010: University of South Florida Leadership Institute

2008-2011: Dean’s Academic Performance Award, Recognition for outstanding contribution to the Mission of the College of Medicine, University of South Florida College of Medicine, Tampa, FL.

Research:

Focus Areas: 1) Autonomic control of the heart; 2) Stroke

Grant Proposals Funded (since 2009):

2009-2011: “Synthesis and screening of sigma receptor ligands for stroke therapy at delayed time points.”  Co-Principal Investigator, PI Project 2.
King Biomedical Research Program, State of Florida, ($ 764,174, total costs for two years; Project 2: $156,965, total cost for two years).

2009-2011: “Effects of Afobasol on Calcium Handling in Neurons During Ischemia” Principal Investigator, RF Pharmaceuticals Sarl, ($44,825, total costs for one year).

2009-2011: “Effects of Afobasol on Calcium Handling in Neurons and Microglia” Principal Investigator, MDR Pharmaceutical Limited, ($85,298, total costs for one year).

2010-2012: “Role of Calcium in Mediating c-HYD1 and HYD1 Induced Cell Death in Multiple Myeloma” Collaborator, Multiple Myeloma Research Foundation, ($200,000, total costs for two tears; $13,982 sub award), Lori Hazlehurst, PI.

2011-2012: “Neuroprotective properties of Afobasol modeled in vitro” Principal Investigator, MDR Pharmaceutical Limited, ($93,767, total costs for one year).

2011-2013: “Effects of Afobasol in Rat Model of Ischemic Stroke” Principal Investigator, MDR Pharmaceutical Limited, ($369,968.73, total costs for two years).

2011-2013: "Molecular mechanisms of sigma receptor-mediated cytoprotection.” Principal Investigator, American Heart Association
Grant-In-Aid, Greater Southeastern Affiliate (11GRNT7990120; $165,000).

Publications:

Refereed journal articles (last 5 years):
  1. McCord, A.M., Cuevas, J., and Anderson, B. (2007). Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. DNA and Cell Biol. 26:657-663.
  2. Song, S., Song, S., Zhang, H., Cuevas, J., and Sanchez-Ramos, J. (2007). Comparison of neurons derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem Cells and Development 16:747-756.
  3. Herrera, Y., Katnik, C., Rodriguez, J.D., Hall, A.A., Willing, A., Pennypacker, K.R., and Cuevas, J. (2008). Sigma-1 receptor modulation of ASIC1a channels and ASIC1a-induced Ca2+ influx in rat cortical neurons. J. Pharmacol. Exp. Ther. 327:491-502.
  4. Pollock, V.V., Pastoor, T., Katnik, C., Cuevas, J. and Wecker, L. (2009). Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate α4β2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience 158:1311-1325.
  5. Hall, A.A., Herrera, Y., Ajmo C.T., Cuevas, J.*, Pennypacker K.R. (2009).  Sigma receptors suppress multiple aspects of microglial activation. Glia 57:744-754. *corresponding author
  6. Ajmo, T.C., Collier, L.A., Leonardo, C.C., Hall, A.A., Green, S.M., Cuevas, J., Willing, A.E., Pennypacker, K.R. (2009). Blockade of adrenoreceptors inhibits the splenic response to stroke.  Exp. Neuro. 218:47-55.
  7. Zhang, H., Katnik, C. and Cuevas, J. (2009).  Sigma Receptor Activation Inhibits Voltage-Gated Sodium Channels in Rat Intracardiac Ganglion Neurons. IJPPP. 2:1-11
  8. Cortes-Salva, M.Y., Nguyen, B-L, Cuevas, J., Pennypacker, K.R., and Antilla, J.C. (2010) Copper-Catalyzed Cross Guanidinylation of Aryl Iodides: The Formation of N,N’-Disubstituted Guanidines. Organic Letters 12:1316-1319.
  9. Mari, Y., Katnik, C., and Cuevas, J. (2010). ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular calcium overload during ischemia and acidosis. Cell Calcium 48:70-82.
  10. Yanamandra, N., Buzzeo, R.W., Gabriel, M., Mari, Y., Beaupre, D.M., Cuevas, J.  (2011).  Tipifarnib-induced apoptosis in acute myeloid leukemia cells is dependent on Ca2+ influx through plasma membrane Ca2+ channels. J. Pharmacol. Exp. Ther. 337:636-643.
  11. Cuevas, J., Behensky, A. and Katnik, C. (2011). Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors. J. Pharmacol. Exp. Ther. 339:152-160.
  12. Cuevas, J., Rodriguez, A., Behensky, A. and Katnik, C. (2011).  Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors. J. Pharmacol. Exp. Ther. 339:161-172. 

Patents:

2005: Effective Treatment with Sigma Receptor Agonists Post-Stroke. USF Ref: 05A046PRC, U.S. patent pending.

2005: Screening for New Agents for Post-Stroke Treatment. USF-05B105, U.S. patent pending.

2009: Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins, United States Patent 7563595.

2010: N, N'-di-p-bromophenyl Guanidine Treatment for Stroke at Delayed Timepoints. 08A048PRWOUS, U.S. patent pending.

2011: Targeting Orai3 for cancer chemotherapy.  08B089PRC, Patent pending.

2011: Creation of ischemic penumbra on a chip.  Patent pending.

Service:

Scientific Advisory Board 

2008-present: American Heart Association Greater Southeast Affiliate Research Committee

University Service:

2003-present: Faculty Advisor, McNair Scholars Program

2004-present: Faculty Advisor, Latino Medical Student Association

2005-present: Faculty Advisor, Marc/U-STAR Scholars Program

Community Service:

2009-present: Medical Mission to Dilaire, Haiti; Director

Faculty Council Goals:

The next few years will pose significant challenges to USF Morsani College of Medicine as we adapt to the economic realities of decreased funding from state and federal sources and changes to healthcare reimbursement, while at the same time growing as an institution.  In addition, our faculty are being impacted by major changes, such as the structure of the curriculum, the manner in which we are evaluated by the administration, and the leadership organization of our college.  The USF MCOM Faculty Council needs to enhance participation of faculty, many of whom have become disengaged, and foster a culture of joint governance with the administration to influence the direction setting process.  Ultimately, the increased input from our talented faculty will enrich our college of medicine and improve faculty satisfaction.