Edgar Espana, MD

Assistant Professor, College Of Medicine Molecular Pharmacology & Physiology

Assistant Professor, College Of Medicine Ophthalmology

Assistant Professor, College Of Medicine Pathology & Cell Biology

College Of Medicine Ophthalmology

Assistant Professor, Pathology, University of South Florida

Assistant Professor, Ophthalmology, University of South Florida

Contact Info USF Eye Institue
12901 Bruce B Downs Boulevard
Tampa, FL 33612

Academic Email: eespana@health.usf.edu

Education

  • Flw, Cornea Fellowship, Cleveland Clinic, 2011
  • Res, Ophthalmology Residency, Univ of Mississippi, 2010
  • MD, Medicine, Pontificia Universidad Javeriana, 1996

Research Interests

  • Separation of Descemet's membrane from stroma. Endothelial maturation. Expansion of corneal stem cells. Clinical uses and biological properties of human amniotic membrane. DSAEK (Posterior endothelial corneal transplantation).

Memberships

  • American Academy of Ophthalmology (Ophthalmologist, 2005 - Present)
  • Association for Research in Vision and Ophthalmology (Member, 2001 - Present)

Recent Publications

  • Shah, S.Espana, EM.Margo, CE. Ocular manifestations of monoclonal copper-binding immunoglobulin. Survey of ophthalmology. 59(1) : 115-23http://www.ncbi.nlm.nih.gov/pubmed/24112547
  • Espana, EM.Shah, S.Santhiago, MR.Singh, AD. Graft versus host disease: clinical evaluation, diagnosis and management. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/23504086
  • Sabater, AL.Guarnieri, A.Espana, EM.Li, W.Prósper, F.Moreno-Montañés, J. Strategies of human corneal endothelial tissue regeneration. Regenerative medicine. 8(2) : 183-95, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23477398
  • Kawakita, T.Espana, EM.Higa, K.Kato, N.Li, W.Tseng, SC. Activation of Smad-mediated TGF-β signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells. Journal of cellular physiology. 228(1) : 225-34, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22674610
  • Hemmavanh, C.Koch, M.Birk, DE.Espana, EM. Abnormal Corneal Endothelial Maturation in Collagen XII and XIV Null Mice. Investigative ophthalmology & visual science. 54(5) : 3297-308, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23599329
  • Bui, AQ.Espana, EM.Margo, CE. Chromoblastomycosis of the conjunctiva mimicking melanoma of the ciliary body. Archives of ophthalmology. 130(12) : 1615-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23229710
  • Gomes, BA.Smadja, D.Espana, EM.Ahn, ES.Netto, MV.Santhiago, MR. Very late-onset corneal scar triggered by trauma after photorefractive keratectomy. Journal of cataract and refractive surgery. 38(9) : 1694-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22906452
  • Smadja, D.Santhiago, MR.Mello, GR.Espana, EM.Krueger, RR. Suction loss during thin-flap femto-LASIK: management and beneficial refractive effect of the epithelium. Journal of cataract and refractive surgery. 38(5) : 902-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22405992
  • Santhiago, MR.Wilson, SE.Netto, MV.Ghanen, RC.Monteiro, ML.Bechara, SJ.Espana, EM.Mello, GR.Kara, N. Modulation transfer function and optical quality after bilateral implantation of a +3.00 D versus a +4.00 D multifocal intraocular lens. Journal of cataract and refractive surgery. 38(2) : 215-20, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22104642
  • Santhiago, MR.Smadja, D.Zaleski, K.Espana, EM.Armstrong, BK.Wilson, SE. Flap relift for retreatment after femtosecond laser-assisted LASIK. Journal of refractive surgery (Thorofare, N.J. : 1995). 28(7) : 482-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22767166
  • Espana, EM.Huang, B.Fratkin, J.Henegar, J. An enzymatic technique to facilitate air separation of the stroma-Descemet's membrane junction. Investigative ophthalmology & visual science. 52(13) : 9327-32, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21969297
  • Espana, EM.Levine, M.Schoenfield, L.Singh, AD. Ocular surface squamous neoplasia in an anophthalmic socket 60 years after enucleation. Survey of ophthalmology. 56(6) : 539-43, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22117887
  • Espana, EM.Acosta, AC.Stoiber, J.Fernandez, V.Lamar, PD.Villain, FL.Lacombe, E.Alfonso, E.Parel, JM. Long-term follow-up of a supradescemetic keratoprosthesis in rabbits: an immunofluorescence study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 249(2) : 253-60, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20814695
  • Espana, EM.Huang, B. Confocal microscopy study of donor-recipient interface after Descemet's stripping with endothelial keratoplasty. The British journal of ophthalmology. 94(7) : 903-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19825836
  • Espana, EM.Robertson, ZM.Huang, B. Intraocular pressure changes following Descemet's stripping with endothelial keratoplasty. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 248(2) : 237-42, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19936776
  • Espana, EM.Ioannidis, A.Tello, C.Liebmann, JM.Foster, P.Ritch, R. Urrets-Zavalia syndrome as a complication of argon laser peripheral iridoplasty. The British journal of ophthalmology. 91(4) : 427-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/16987896
  • Espana, EM.Acosta, AC.Nose, I.Orozco, M.Fantes, F.Yoo, SH.Parel, JM. Validation of the Barraquer tonometer for high intraocular pressure estimation. Journal of refractive surgery (Thorofare, N.J. : 1995). 22(6) : 580-4, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16805121
  • Espana, EM.Kawakita, T.Di Pascuale, MA.Li, W.Yeh, LK.Parel, JM.Liu, CY.Tseng, SC. The heterogeneous murine corneal stromal cell populations in vitro. Investigative ophthalmology & visual science. 46(12) : 4528-35, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16303944
  • Espana, EM.Di Pascuale, MA.He, H.Kawakita, T.Raju, VK.Liu, CY.Tseng, SC. Characterization of corneal pannus removed from patients with total limbal stem cell deficiency. Investigative ophthalmology & visual science. 45(9) : 2961-6, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15326108
  • Espana, EM.Kawakita, T.Liu, CY.Tseng, SC. CD-34 expression by cultured human keratocytes is downregulated during myofibroblast differentiation induced by TGF-beta1. Investigative ophthalmology & visual science. 45(9) : 2985-91, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15326111
  • Espana, EM.He, H.Kawakita, T.Di Pascuale, MA.Raju, VK.Liu, CY.Tseng, SC. Human keratocytes cultured on amniotic membrane stroma preserve morphology and express keratocan. Investigative ophthalmology & visual science. 44(12) : 5136-41, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14638709
  • Espana, EM.Kawakita, T.Romano, A.Di Pascuale, M.Smiddy, R.Liu, CY.Tseng, SC. Stromal niche controls the plasticity of limbal and corneal epithelial differentiation in a rabbit model of recombined tissue. Investigative ophthalmology & visual science. 44(12) : 5130-5, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14638708
  • Espana, EM.Romano, AC.Kawakita, T.Di Pascuale, M.Smiddy, R.Tseng, SC. Novel enzymatic isolation of an entire viable human limbal epithelial sheet. Investigative ophthalmology & visual science. 44(10) : 4275-81, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14507871
  • Espana, EM.Ti, SE.Grueterich, M.Touhami, A.Tseng, SC. Corneal stromal changes following reconstruction by ex vivo expanded limbal epithelial cells in rabbits with total limbal stem cell deficiency. The British journal of ophthalmology. 87(12) : 1509-14, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14660463

Awards/Honors

  • William C Edwards Excellence in Teaching Award (Ophthalmology Residents - 2012)
  • ARVO/Alcon Early Career Clinician Scientist Research Awards (ARVO - 2012)