Marcia Gordon K-2420-2012

Marcia Gordon, Ph.D.

Professor, Department of Molecular Pharmacology and Physiology

Contact Info USF Health Byrd Alzheimer's Institute
4001 E. Fletcher Ave.
Tampa FL 33613

Academic Email: mgordon@health.usf.edu

Academic Phone:(813) 974-9926

View My C.V.

Education

  • PHD, Molecular Biology, University of Southern California, 1985

Interdisciplinary and Emerging Signature Programs

  • Cellular and Molecular Biology
  • Neurodegenerative Disease
  • Neuroscience

Research Interests

  • * Experimental therapeutics for Alzheimer's disease using animal models
  • * Role of glial cells and neuroinflammation in neurodegeneration
  • * Development of neuroprotective therapeutics

Memberships

  • Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART (Member, 2014 - Present)
  • Alliance of Women Alzheimer's Researchers (AWARE) (Member, 2014 - Present)
  • American Society for Neural Therapy and Repair (Member, 2008 - Present)
  • Society for Neuroscience (member, 1980 - Present)

Recent Publications

  • Schroeder S, Joly-Amado A, Soliman A, Sengupta U, Kayed R, Gordon MN, Morgan D. Oligomeric tau-targeted immunotherapy in Tg4510 mice. Alzheimer's research & therapy. 9(1) : 46, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28655349
  • Schroeder SK, Joly-Amado A, Gordon MN, & Morgan D. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology. 11(1) : 9-25, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26538351
  • Joly-Amado A, Serraneau KS, Brownlow M, Marín de Evsikova C, Speakman JR, Gordon MN, Morgan D. Metabolic changes over the course of aging in a mouse model of tau deposition. Neurobiology of aging. 44: 62-73, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27318134
  • Nash KR & Gordon MN. Convection Enhanced Delivery of Recombinant Adeno-associated Virus into the Mouse Brain. Methods in Molecular Biology (Clifton, N.J.). 1382: 285-95, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26611595
  • Selenica MB, Reid P, Pena G, Alvarez J, Hunt JB, Nash KR, Morgan D, Gordon MN, & Lee DC. Adeno associated viral-mediated intraosseous labeling of bone marrow derived cells for CNS tracking. Journal of Immunological Methods. , 2016. http://www.ncbi.nlm.nih.gov/pubmed/26784524
  • Hunt JB, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, Sandusky LA, Gordon MN, Morgan D, & Lee DC. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of Neuroscience : the official journal of the Society for Neuroscience. 35(44) : 14842-60, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26538654
  • Selenica ML, Benner L, Housley SB, Manchec B, Lee DC, Nash KR, Kalin J, Bergman JA, Kozikowski A, Gordon MN, Morgan D. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition. Alzheimer's research & therapy. 6(1) : 12, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24576665
  • Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of neuroinflammation. 11: 152, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25183004
  • Brownlow ML, Joly-Amado A, Azam S, Elza M, Selenica ML, Pappas C, Small B, Engelman R, Gordon MN, & Morgan D. Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition. Behavioural Brain Research. 271: 79-88, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24925454
  • Joly-Amado A, Brownlow M, Pierce J, Ravipati A, Showalter E, Li Q, Gordon MN, Morgan D. Intraventricular human immunoglobulin distributes extensively but fails to modify amyloid in a mouse model of amyloid deposition. Current Alzheimer research. 11(7) : 664-71, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25115543
  • Selenica ML, Alvarez JA, Nash KR, Lee DC, Cao C, Lin X, Reid P, Mouton PR, Morgan D, Gordon MN. Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. Journal of neuroinflammation. 10: 86, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23866683
  • Carty N, Nash KR, Brownlow M, Cruite D, Wilcock D, Selenica ML, Lee DC, Gordon MN, Morgan D. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. PloS one. 8(3) : e59626, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23555730
  • Lee DC, Ruiz CR, Lebson L, Selenica ML, Rizer J, Hunt JB, Rojiani R, Reid P, Kammath S, Nash K, Dickey CA, Gordon M, Morgan D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of aging. 34(6) : 1610-20, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23481567
  • Nash KR, Lee DC, Hunt JB, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiology of aging. 34(6) : 1540-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23332170
  • Brownlow ML, Benner L, D'Agostino D, Gordon MN, Morgan D. Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PloS one. 8(9) : e75713, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24069439
  • Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neuro-degenerative diseases. 11(4) : 165-81, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22796753
  • Lee DC, Rizer J, Hunt JB, Selenica ML, Gordon MN, Morgan D. Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathology and applied neurobiology. 39(1) : 69-85, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23171029
  • Li Q, Lebson L, Lee DC, Nash K, Grimm J, Rosenthal A, Selenica ML, Morgan D, Gordon MN. Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 7(1) : 202-14, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22198698
  • Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA. Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. Journal of neuroinflammation. 8: 115, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21906275
  • Wilcock DM, Zhao Q, Morgan D, Gordon MN, Everhart A, Wilson JG, Lee JE, Colton CA. Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. ASN neuro. 3(5) : 249-58, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21995345
  • Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of neuroscience methods. 194(1) : 144-53, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20951738
  • Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of neuroinflammation. 7: 56, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20846376
  • Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee DC, Li Q, Szekeres K, Jinwal U, Koren J, Dickey CA, Gottschall PE, Morgan D, Gordon MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(29) : 9651-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20660248
  • Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Journal of neurochemistry. 113(3) : 784-95, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20180882
  • Li QY, Gordon MN, Chackerian B, Alamed J, Ugen KE, Morgan D. Virus-like peptide vaccines against Abeta N-terminal or C-terminal domains reduce amyloid deposition in APP transgenic mice without addition of adjuvant. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 5(1) : 133-42, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20066498

Awards/Honors

  • Silver Performance Award for Outstanding Contributions (University of South Florida Health - 2007)
  • Travel Award (University of Michigan Claude D. Pepper Geriatrics Research and Training Center - 1992)
  • Travel Award (American Society of Neurochemistry - 1989)
  • Postdoctoral Fellowship (Brain Research Institute and Department of Anatomy, University of California at Los Angeles - 1987)
  • Postdoctoral Fellowship (Mental Retardation Research Center, University of California at Los Angeles - 1985)
  • Predoctoral Fellowship (Andrus Gerontology Center, University of Southern California - 1982)
  • Teaching Assistant Fellowship (Department of Biological Sciences, University of Southern California - 1978)