Edwin Weeber

Edwin Weeber, Ph.D.

Professor, Molecular Pharmacology & Physiology

Chief Scientific Officer, USF Health Byrd Alzheimer's Institute

Director, Murine Neurobehavioral Testing Facility

Professor, College of Medicine Molecular Pharmacology & Physiology

Associate Professor, Molecular Pharmacology and Physiology

Contact Info 4001 E Fletcher Ave
Byrd 310
Tampa FL 33613

Academic Email: eweeber@health.usf.edu

Academic Phone:(813) 396-9995

View My C.V.


  • PhD, Neuroscience, University of New Mexico, 1999

Interdisciplinary and Emerging Signature Programs

  • Biomedical Engineering & Nanomedicine
  • Neuroscience

Research Interests

  • The laboratory research programs center on reelin, Angelman Syndrome, ApoE and Alzheimer's Disease and neuroprosthetics.
  • For details please visit the laboratoory website
  • www.weeberlab.com


  • American Society for Neurochemistry (ASN) (Member, 2004 - Present)
  • American Academy for the Advancement of Science (AAAS) (Member, 2004 - Present)
  • Molecular and Cellular Cognition Society (Member, 2002 - Present)
  • Society for Neuroscience (SFN) (Member, 1999 - Present)
  • Society for the Advancement of Chicanos and Native Americans in Science (Member, 1995 - Present)

Recent Publications

  • Born HA, Dao AT, Levine AT, Lee WL, Mehta NM, Mehra S, Weeber EJ, Anderson AE. Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice. Scientific reports. 7(1) : 8451, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28814801
  • Grieco JC, Bahr RH, Schoenberg MR, Conover L, Mackie LN, Weeber EJ. Quantitative Measurement of Communication Ability in Children with Angelman Syndrome. Journal of applied research in intellectual disabilities : JARID. , 2016. http://www.ncbi.nlm.nih.gov/pubmed/27990716
  • Lussier AL, Weeber EJ, Rebeck GW. Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration. Frontiers in Cellular Neuroscience. 10: 75, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27065802
  • Ciarlone SL, Grieco JC, D'Agostino DP, Weeber EJ. Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model. Neurobiology of disease. 96: 38-46, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27546058
  • Ciarlone S L, and Weeber EJ. Towards targeted therapy for Angelman syndrome. Exp Opin on Orphan Drugs.. 4(3) : 317-325., 2016.
  • Ciarlone SL, Wang X, Rogawski MA, Weeber EJ. Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model. Neuropharmacology. 116: 142-150, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27986596
  • DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, Rebeck GW, Hoe HS. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner. Biochimica et Biophysica Acta. 1853(5) : 904-17, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25644714
  • Woo JA, Boggess T, Uhlar C, Wang X, Khan H, Cappos G, Joly-Amado A, De Narvaez E, Majid S, Minamide LS, Bamburg JR, Morgan D, Weeber E, Kang DE. RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell Death & Disease. 6: 1676, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25741591
  • Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death and Differentiation. 22(6) : 921-34, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25698445
  • Hethorn WR, Ciarlone SL, Filonova I, Rogers JT, Aguirre D, Ramirez RA, Grieco JC, Peters MM, Gulick D, Anderson AE, L Banko J, Lussier AL, Weeber EJ. Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome. The European Journal of Neuroscience. 41(10) : 1372-80, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25864922
  • Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death and Differentiation. 22(6) : 1069-70, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25941167
  • Nielsen MG, Bernardin T, Hassan K, Kriezis EE, Weeber JC. Silicon-loaded surface plasmon polariton waveguides for nanosecond thermo-optical switching. Optics letters. 39(8) : 2282-5, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24978973
  • Trotter JH, Lussier AL, Psilos KE, Mahoney HL, Sponaugle AE, Hoe HS, Rebeck GW, Weeber EJ. Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation. Neuroscience. 274: 299-307, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24892761
  • Divekar SD, Burrell TC, Lee JE, Weeber EJ, Rebeck GW. Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2. The Journal of biological chemistry. 289(23) : 15894-903, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24755222
  • Song S, Wang X, Sava V, Weeber EJ, Sanchez-Ramos J. In vivo administration of granulocyte colony-stimulating factor restores long-term depression in hippocampal slices prepared from transgenic APP/PS1 mice. Journal of neuroscience research. 92(8) : 975-80, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24664800
  • Rueli RH, Parubrub AC, Dewing AS, Hashimoto AC, Bellinger MT, Weeber EJ, Uyehara-Lock JH, White LR, Berry MJ, Bellinger FP. Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain. Journal of Alzheimer's Disease : JAD. , 2014. http://www.ncbi.nlm.nih.gov/pubmed/25298198
  • Burrell TC, Divekar SD, Weeber EJ, Rebeck GW. Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. PloS one. 9(10) : e110845, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25340851
  • Grieco JC, Ciarlone SL, Gieron-Korthals M, Schoenberg MR, Smith AG, Philpot RM, Heussler HS, Banko JL, Weeber EJ. An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome. BMC neurology. 14(1) : 232, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25491305
  • Filonova I, Trotter JH, Banko JL, Weeber EJ. Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model. Learning & Memory (Cold Spring Harbor, N.Y.). 21(2) : 98-104, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24434871
  • Rogers JT, Zhao L, Trotter JH, Rusiana I, Peters MM, Li Q, Donaldson E, Banko JL, Keenoy KE, Rebeck GW, Hoe HS, D'Arcangelo G, Weeber EJ. Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse. Journal of psychopharmacology (Oxford, England). 27(4) : 386-95, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23104248
  • Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learning & memory (Cold Spring Harbor, N.Y.). 20(5) : 256-66, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23592036
  • Trotter J, Lee GH, Kazdoba TM, Crowell B, Domogauer J, Mahoney HM, Franco SJ, Müller U, Weeber EJ, D'Arcangelo G. Dab1 is required for synaptic plasticity and associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(39) : 15652-68, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24068831
  • Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. 74(5) : 367-74, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23607970
  • Daily J, Smith AG, Weeber EJ. Spatial and temporal silencing of the human maternal UBE3A gene. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 16(6) : 587-91, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22560727
  • Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of biological chemistry. 287(50) : 41774-86, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23060451
  • Zeitlin R, Patel S, Solomon R, Tran J, Weeber EJ, Echeverria V. Cotinine enhances the extinction of contextual fear memory and reduces anxiety after fear conditioning. Behavioural brain research. 228(2) : 284-93, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22137886
  • Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PloS one. 6(2) : e17203, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21347244
  • Reddy SS, Connor TE, Weeber EJ, Rebeck W. Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. Molecular neurodegeneration. 6: 30, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21554715
  • Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(50) : 17068-78, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21159977
  • Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46) : 15374-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21084594
  • Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiology of disease. 39(3) : 283-91, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20423730
  • Qiu S, Champagne DL, Peters M, Catania EH, Weeber EJ, Levitt P, Pimenta AF. Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit. Biological psychiatry. 68(2) : 197-204, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20385375
  • O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5: 45, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21040568
  • Korwek KM, Trotter JH, Ladu MJ, Sullivan PM, Weeber EJ. ApoE isoform-dependent changes in hippocampal synaptic function. Molecular neurodegeneration. 4: 21, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19725929
  • Frewin CL, Jaroszeski M, Weeber E, Muffly KE, Kumar A, Peters M, Oliveros A, Saddow SE. Atomic force microscopy analysis of central nervous system cell morphology on silicon carbide and diamond substrates. Journal of molecular recognition : JMR. 22(5) : 380-8, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19585542
  • Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39) : 12079-88, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19793966
  • Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48) : 15317-22, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19955384
  • Yamagata T, Urano H, Weeber EJ, Nelson DL, Nishijima I. Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience. 154(4) : 1417-22, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18534766
  • Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ, Nguyen PV. Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). 15(6) : 403-11, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18509114
  • Levenson JM, Qiu S, Weeber EJ. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Biochimica et biophysica acta. 1779(8) : 422-31, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18237558
  • Fan D, Yancey PG, Qiu S, Ding L, Weeber EJ, Linton MF, Fazio S. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry. 47(6) : 1631-9, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18197702
  • Rogers JT, Weeber EJ. Reelin and apoE actions on signal transduction, synaptic function and memory formation. Neuron glia biology. 4(3) : 259-70, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19674510
  • Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 18(8) : 814-23, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18493953
  • Bolognani F, Qiu S, Tanner DC, Paik J, Perrone-Bizzozero NI, Weeber EJ. Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD. Neurobiology of learning and memory. 87(4) : 635-43, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17185008
  • Qiu S, Weeber EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. Journal of neurophysiology. 97(3) : 2312-21, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17229826
  • van Woerden GM, Harris KD, Hojjati MR, Gustin RM, Qiu S, de Avila Freire R, Jiang YH, Elgersma Y, Weeber EJ. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nature neuroscience. 10(3) : 280-2, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17259980
  • Qiu S, Li L, Weeber EJ, May JM. Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. Journal of neuroscience research. 85(5) : 1046-56, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17304569
  • Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, Winfrey VP, Austin LM. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(23) : 6207-11, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17553992
  • Gelinas JN, Banko JL, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. The Journal of biological chemistry. 282(37) : 27527-35, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17635924
  • Chan CS, Weeber EJ, Zong L, Fuchs E, Sweatt JD, Davis RL. Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(1) : 223-32, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16399691
  • Rebeck GW, LaDu MJ, Estus S, Bu G, Weeber EJ. The generation and function of soluble apoE receptors in the CNS. Molecular neurodegeneration. 1: 15, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17062143
  • Qiu S, Zhao LF, Korwek KM, Weeber EJ. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(50) : 12943-55, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17167084
  • Peters MM, Hill KE, Burk RF, Weeber EJ. Altered hippocampus synaptic function in selenoprotein P deficient mice. Molecular neurodegeneration. 1: 12, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16984644
  • Beffert U, Durudas A, Weeber EJ, Stolt PC, Giehl KM, Sweatt JD, Hammer RE, Herz J. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(7) : 2041-52, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16481437
  • Qiu S, Korwek KM, Pratt-Davis AR, Peters M, Bergman MY, Weeber EJ. Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice. Neurobiology of learning and memory. 85(3) : 228-42, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16376115
  • Qiu S, Korwek KM, Weeber EJ. A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiology of learning and memory. 85(1) : 16-29, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16198608
  • Nishijima I, Yamagata T, Spencer CM, Weeber EJ, Alekseyenko O, Sweatt JD, Momoi MY, Ito M, Armstrong DL, Nelson DL, Paylor R, Bradley A. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Human molecular genetics. 15(21) : 3241-50, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17008357
  • Sinagra M, Verrier D, Frankova D, Korwek KM, Blahos J, Weeber EJ, Manzoni OJ, Chavis P. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(26) : 6127-36, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15987942
  • Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li WP, Adelmann G, Frotscher M, Hammer RE, Herz J. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 47(4) : 567-79, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16102539
  • Marschang P, Brich J, Weeber EJ, Sweatt JD, Shelton JM, Richardson JA, Hammer RE, Herz J. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Molecular and cellular biology. 24(9) : 3782-93, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15082773
  • Opal P, Garcia JJ, McCall AE, Xu B, Weeber EJ, Sweatt JD, Orr HT, Zoghbi HY. Generation and characterization of LANP/pp32 null mice. Molecular and cellular biology. 24(8) : 3140-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15060138
  • Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(8) : 1897-906, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14985430
  • Strasser V, Fasching D, Hauser C, Mayer H, Bock HH, Hiesberger T, Herz J, Weeber EJ, Sweatt JD, Pramatarova A, Howell B, Schneider WJ, Nimpf J. Receptor clustering is involved in Reelin signaling. Molecular and cellular biology. 24(3) : 1378-86, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14729980
  • May P, Rohlmann A, Bock HH, Zurhove K, Marth JD, Schomburg ED, Noebels JL, Beffert U, Sweatt JD, Weeber EJ, Herz J. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Molecular and cellular biology. 24(20) : 8872-83, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15456862
  • Weeber EJ, Caldwell KK. Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex. Pharmacology, biochemistry, and behavior. 78(1) : 155-64, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15159145
  • Weeber EJ, Jiang YH, Elgersma Y, Varga AW, Carrasquillo Y, Brown SE, Christian JM, Mirnikjoo B, Silva A, Beaudet AL, Sweatt JD. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7) : 2634-44, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12684449
  • Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 37(2) : 233-47, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12546819
  • Sweatt JD, Weeber EJ, Lombroso PJ. Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(6) : 741-4, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12921483
  • Chan CS, Weeber EJ, Kurup S, Sweatt JD, Davis RL. Integrin requirement for hippocampal synaptic plasticity and spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(18) : 7107-16, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12904471
  • Sweatt JD, Weeber EJ. Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(7) : 873-6, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12819448
  • Yoo SY, Pennesi ME, Weeber EJ, Xu B, Atkinson R, Chen S, Armstrong DL, Wu SM, Sweatt JD, Zoghbi HY. SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron. 37(3) : 383-401, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12575948
  • Selcher JC, Weeber EJ, Christian J, Nekrasova T, Landreth GE, Sweatt JD. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learning & memory (Cold Spring Harbor, N.Y.). 10(1) : 26-39, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12551961
  • Weeber EJ, Levenson JM, Sweatt JD. Molecular genetics of human cognition. Molecular interventions. 2(6) : 376-91, 339, 2002. http://www.ncbi.nlm.nih.gov/pubmed/14993414
  • Watase K, Weeber EJ, Xu B, Antalffy B, Yuva-Paylor L, Hashimoto K, Kano M, Atkinson R, Sun Y, Armstrong DL, Sweatt JD, Orr HT, Paylor R, Zoghbi HY. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron. 34(6) : 905-19, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12086639
  • Weeber EJ, Beffert U, Jones C, Christian JM, Forster E, Sweatt JD, Herz J. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. The Journal of biological chemistry. 277(42) : 39944-52, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12167620
  • Levenson JM, Weeber EJ, Sweatt JD, Eskin A. Glutamate uptake in synaptic plasticity: from mollusc to mammal. Current molecular medicine. 2(7) : 593-603, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12420799
  • Selcher JC, Weeber EJ, Varga AW, Sweatt JD, Swank M. Protein kinase signal transduction cascades in mammalian associative conditioning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 8(2) : 122-31, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11954557
  • Gu Y, McIlwain KL, Weeber EJ, Yamagata T, Xu B, Antalffy BA, Reyes C, Yuva-Paylor L, Armstrong D, Zoghbi H, Sweatt JD, Paylor R, Nelson DL. Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7) : 2753-63, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11923441
  • Weeber EJ, Levy M, Sampson MJ, Anflous K, Armstrong DL, Brown SE, Sweatt JD, Craigen WJ. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. The Journal of biological chemistry. 277(21) : 18891-7, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11907043
  • Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, Eskin A. Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nature neuroscience. 5(2) : 155-61, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11788834
  • Weeber EJ, Sweatt JD. Molecular neurobiology of human cognition. Neuron. 33(6) : 845-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11906692
  • Weeber EJ, Savage DD, Sutherland RJ, Caldwell KK. Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiology of learning and memory. 76(2) : 151-82, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11502147
  • Dineley KT, Weeber EJ, Atkins C, Adams JP, Anderson AE, Sweatt JD. Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination. Journal of neurochemistry. 77(4) : 961-71, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11359861
  • Seung Kim HF, Weeber EJ, Sweatt JD, Stoll AL, Marangell LB. Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. Molecular psychiatry. 6(2) : 246-8, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11317232
  • Mirnikjoo B, Brown SE, Kim HF, Marangell LB, Sweatt JD, Weeber EJ. Protein kinase inhibition by omega-3 fatty acids. The Journal of biological chemistry. 276(14) : 10888-96, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11152679
  • Weeber EJ, Atkins CM, Selcher JC, Varga AW, Mirnikjoo B, Paylor R, Leitges M, Sweatt JD. A role for the beta isoform of protein kinase C in fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(16) : 5906-14, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10934237
  • Allan AM, Weeber EJ, Savage DD, Caldwell KK. Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring. Alcoholism, clinical and experimental research. 21(8) : 1534-41, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9394128

Positions Held

  • Assistant Professor (Department of Neuroscience, Baylor College of Medicine 2003 - 2004)
  • Reasearch Instructor (Department of Neuroscience, Baylor College of Medicine 2002 - 2003)


  • Federation European Neuroscience Societies (FENS) Scientific Highlight of the Year Award 2008)
  • Med Scholars Mentoring Award (VUMC) 2006)
  • National Alliance for Research on Schizophrenia and Depression (NARSAD) Award 2004)
  • Cynthia and George Mitchell Award in Dementia Research 2003)
  • American Federation for Aging Research (AFAR) Award 2003)