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Jun Tan, M.D., Ph.D.
Robert A. Silver Chair in Developmental Neurobiology
Associate Professor
Director of Developmental Neurobiology Laboratory
Silver Child Development Center
| Contact Information |
Developmental Neurobiology Laboratory
Silver Child Development Center
Department of Psychiatry & Behavioral Medicine
12901 Bruce B. Downs Blvd., MDC 102
Tampa, Florida 33612-4742
Telephone: (813) 974-9326
Fax: (813) 974-1130
E-mail: jtan@hsc.usf.edu |
| Education |
- 1996-1998 Post-Doc., Immunology Program, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA
- 1994-1996 Post-Doc., Department of Medical Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 1990-1992 Ph.D., Immunology, Third Military Medical University, Chongqing, China
- 1987-1989 M.S., Human Genetics, Institute of Genetics of Fudan University, Shanghai, China
- 1978-1983 M.D. training (B.Ms.), Medicine, Third Military Medical University, Chongqing, China |
| Interests |
We are interested in developing the novel treatments for Alzheimer’s disease (AD) and other neurodegenerative disorders (HIV dementia). For this purpose, we have established transdermal and other alternative vaccines for AD in mouse models of the disease. In addition, we have discovered the natural compounds in promoting amyloid precursor protein (APP) α-secretase cleavage or inhibiting γ-secretase activity both in various cell systems and as well as in animal models. Moreover, we have analyzed the role of microglial activation in modulation of AD-like pathology in experimental animal modes following administration of human umbilical cord blood cells. |
| Publications |
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- 1. Nikolic V, Town T, Mori T, Ehrhart J, Zeng J, Luo, D, Sanberg CD, Giunta B, Sanberg PR and Tan J. Peripherally administered human umbilical cord blood cells reduce Aβ plaque load in an Alzheimer’s mouse model. Journal of Immunology (2007, re-revised).
- Obregon D, Hou H, Bai Y, Nikolic VW, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T and Tan J. CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. Neurobiology of Diseases doi: 10.1016/j.nbd.2007.09009.
- Cracchiolo JR, Mori T, Nazian SJ, Tan J, Potter H, Arendash GW. Enhanced cognitive activity-over and above social or physical activity-is required to protect Alzheimer's mice against cognitive impairment, reduce Aβ deposition, and increase synaptic immunoreactivity. Neurobio Learn Mem 2007 Aug 20.
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| Honors/Awards
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- Robert A. Silver Chair in Developmental Neurobiology (2007)
- Investigator-Initiated Award: Alzheimer Association (2003)
- Young Investigator Research Award, National Science Foundation of China, 1992
Achievement Award for Science and Technology in China, 1994
- National Outstanding Oversea Young Scientist Award, National Science Foundation of China, 2002
- 2002 Principal Investigator-Alzheimer Association-IIRG-02-4064-Role of CD40L in Gliosis and Amyloidosis in Alzheimer Transgenic Mice
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